Xiao Fei, Sun Li-Ying, Wei Lin, Zeng Zhi-Gui, Qu Wei, Liu Ying, Zhang Hai-Ming, Zhu Zhi-Jun
Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Clinical Center for Pediatric Liver Transplantation, Capital Medical University, Beijing 100050, China.
World J Clin Cases. 2021 Apr 16;9(11):2649-2654. doi: 10.12998/wjcc.v9.i11.2649.
Laparoscopic living donor hepatectomy (LLDH) has been successfully carried out in several transplant centers. Biliary reconstruction is key in living donor liver transplantation (LDLT). Reliable biliary reconstruction can effectively prevent postoperative biliary stricture and leakage. Although preoperative magnetic resonance cholangiopancreatography and intraoperative indocyanine green cholangiography have been shown to be helpful in determining optimal division points, biliary variability and limitations associated with LLDH, multiple biliary tracts are often encountered during surgery, which inhibits biliary reconstruction. A reliable cholangiojejunostomy for multiple biliary ducts has been utilized in LDLT. This procedure provides a reference for multiple biliary reconstructions after LLDH.
A 2-year-old girl diagnosed with ornithine transcarbamylase deficiency required liver transplantation. Due to the scarcity of deceased donors, she was put on the waiting list for LDLT. Her father was a suitable donor; however, after a rigorous evaluation, preoperative magnetic resonance cholangiopancreatography examination of the donor indicated the possibility of multivessel variation in the biliary tract. Therefore, a laparoscopic left lateral section was performed on the donor, which met the estimated graft-to-recipient weight ratio. Under intraoperative indocyanine green cholangiography, 4 biliary tracts were confirmed in the graft. It was difficult to reform the intrahepatic bile ducts due to their openings of more than 5 mm. A reliable cholangiojejunostomy was, therefore, utilized: Suture of the jejunum to the adjacent liver was performed around the bile duct openings with 6/0 absorbable sutures. At the last follow-up (1 year after surgery), the patient was complication-free.
Intrahepatic cholangiojejunostomy is reliable for multiple biliary ducts after LLDH in LDLT.
腹腔镜活体供肝肝切除术(LLDH)已在多个移植中心成功开展。胆管重建是活体供肝肝移植(LDLT)的关键。可靠的胆管重建可有效预防术后胆管狭窄和渗漏。尽管术前磁共振胰胆管造影和术中吲哚菁绿胆管造影已被证明有助于确定最佳分割点、与LLDH相关的胆管变异性和局限性,但手术中常遇到多条胆管,这会阻碍胆管重建。一种可靠的用于多条胆管的胆管空肠吻合术已应用于LDLT。该手术为LLDH术后的多条胆管重建提供了参考。
一名2岁诊断为鸟氨酸转氨甲酰酶缺乏症的女孩需要进行肝移植。由于脑死亡供体稀缺,她被列入LDLT等待名单。她的父亲是合适的供体;然而,经过严格评估,供体的术前磁共振胰胆管造影检查显示胆管存在多支变异的可能性。因此,对供体实施了腹腔镜左外叶切除术,该切除的肝叶符合预估的供受体重量比。在术中吲哚菁绿胆管造影下,确认移植物中有4条胆管。由于肝内胆管开口超过5mm,难以对其进行整形。因此,采用了一种可靠的胆管空肠吻合术:用6/0可吸收缝线在胆管开口周围将空肠缝合至相邻肝脏。在最后一次随访(术后1年)时,患者无并发症。
在LDLT的LLDH术后,肝内胆管空肠吻合术对多条胆管是可靠的。