Davis Jonathan, Mire Erik
Hodge Centre for Neuropsychiatric Immunology, Neuroscience and Mental Health Research Institute, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
Brain Neurosci Adv. 2021 Apr 8;5:23982128211003484. doi: 10.1177/23982128211003484. eCollection 2021 Jan-Dec.
Maternal obesity is associated with the development of a variety of neuropsychiatric disorders; however, the mechanisms behind this association are not fully understood. Comparison between maternal immune activation and maternal obesity reveals similarities in associated impairments and maternal cytokine profile. Here, we present a summary of recent evidence describing how inflammatory processes contribute towards the development of neuropsychiatric disorders in the offspring of obese mothers. This includes discussion on how maternal cytokine levels, fatty acids and placental inflammation may interact with foetal neurodevelopment through changes to microglial behaviour and epigenetic modification. We also propose an exosome-mediated mechanism for the disruption of brain development under maternal obesity and discuss potential intervention strategies.
母亲肥胖与多种神经精神疾病的发生有关；然而，这种关联背后的机制尚未完全明确。对母亲免疫激活与母亲肥胖进行比较后发现，二者在相关损伤及母亲细胞因子谱方面存在相似之处。在此，我们总结近期证据，阐述炎症过程如何促使肥胖母亲后代发生神经精神疾病。这包括探讨母亲细胞因子水平、脂肪酸和胎盘炎症如何通过小胶质细胞行为改变和表观遗传修饰与胎儿神经发育相互作用。我们还提出了一种外泌体介导的机制，用于解释母亲肥胖状态下脑发育的破坏，并讨论了潜在的干预策略。
