Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.
Maternal-Fetal Medicine, Oregon Health and Science University, Portland, Oregon, USA.
J Leukoc Biol. 2019 Nov;106(5):1035-1050. doi: 10.1002/JLB.3RI0619-181R. Epub 2019 Sep 4.
Maternal pregravid obesity results in several adverse health outcomes during pregnancy, including increased risk of gestational diabetes, preeclampsia, placental abruption, and complications at delivery. Additionally, pregravid obesity and in utero exposure to high fat diet have been shown to have detrimental effects on fetal programming, predisposing the offspring to adverse cardiometabolic, endocrine, and neurodevelopmental outcomes. More recently, a deeper appreciation for the modulation of offspring immunity and infectious disease-related outcomes by maternal pregravid obesity has emerged. This review will describe currently available animal models for studying the impact of maternal pregravid obesity on fetal immunity and review the data from clinical and animal model studies. We also examine the burden of pregravid obesity on the maternal-fetal interface and the link between placental and systemic inflammation. Finally, we discuss future studies needed to identify key mechanistic underpinnings that link maternal inflammatory changes and fetal cellular reprogramming events.
母体妊娠前肥胖会导致孕期出现多种不良健康后果，包括妊娠糖尿病、子痫前期、胎盘早剥和分娩并发症风险增加。此外，妊娠前肥胖和宫内暴露于高脂肪饮食已被证明对胎儿编程有不利影响，使后代易发生不良的心血管代谢、内分泌和神经发育结果。最近，人们对母体妊娠前肥胖对后代免疫和传染病相关结果的调节作用有了更深入的认识。本综述将描述目前用于研究母体妊娠前肥胖对胎儿免疫影响的动物模型，并综述临床和动物模型研究的数据。我们还检查了妊娠前肥胖对母体-胎儿界面的负担以及胎盘和全身炎症之间的联系。最后，我们讨论了未来需要进行研究以确定将母体炎症变化和胎儿细胞重编程事件联系起来的关键机制基础。
