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曼谷 15-19 岁有感染艾滋病毒风险的青少年对血液 HIV 自我检测的可接受性。

Acceptability of blood-based HIV self-testing among adolescents aged 15-19 years at risk of HIV acquisition in Bangkok.

机构信息

Faculty of Medicine, Department of Pediatrics, 26683Chulalongkorn University, Bangkok, Thailand.

Center of Excellence in Transgender Health, 26683Chulalongkorn University, Bangkok, Thailand.

出版信息

Int J STD AIDS. 2021 Sep;32(10):927-932. doi: 10.1177/09564624211003742. Epub 2021 Apr 23.

DOI:10.1177/09564624211003742

PMID:33890847

Abstract

INTRODUCTION

Young men who have sex with men (YMSM) and young transgender women (YTGW) in Thailand are at high HIV risk. HIV self-tests (HIVSTs) are rapidly administrable and prompt linkage to HIV treatment or prevention services. This study assesses the acceptability and feasibility of blood-based HIVST use in adolescents.

METHODS

A cross-sectional study was conducted among YMSM and YTGW aged 15-19 years with HIV acquisition risk. Participants completed questionnaires on the HIVST and then administered INSTI® independently, an HIVST immunoassay detecting gp41 and gp36 antibodies from finger-stick blood. Confirmatory HIV antibody tests were performed.

RESULTS

Between July and September 2020, 90 adolescents were enrolled. Mean (SD) age was 17.6 (1.1) years. Half ( = 45) were YMSM. Forty-six (51%) were first-time HIV testers, and 32 (36%) had "ever used" HIV pre-exposure prophylaxis (PrEP). Two (2.2%, 95% CI: 0.0-5.3) tested positive, 21 (23.4%) invalid, and 67 (74.4%) negative. Invalidity causes included 17 (81%) insufficient blood, 3 (14%) buffer spillage, and 1 (5%) procedural missteps; all had negative HIV antibody tests. HIV self-test acceptability was 87.8% (95% CI: 81.0-94.5). Most (79%) preferred HIVST performance in hospital rather than at home.

CONCLUSIONS

HIVSTs are acceptable in HIV at-risk adolescents. Blood-based HIVSTs should be positioned as rapid point-of-care tests with real-time linkage to HIV services.

摘要

简介

泰国的男男性行为者青年（YMSM）和跨性别青年女性（YTGW）感染 HIV 的风险很高。HIV 自我检测（HIVST）可快速进行，并能及时将 HIV 感染者与 HIV 治疗或预防服务联系起来。本研究评估了基于血液的 HIVST 在青少年中的可接受性和可行性。

方法

在有 HIV 感染风险的 15-19 岁 YMSM 和 YTGW 中进行了一项横断面研究。参与者完成了 HIVST 问卷，然后自行进行 INSTI®检测，这是一种通过手指采血检测 gp41 和 gp36 抗体的 HIVST 免疫测定法。进行了确认 HIV 抗体检测。

结果

在 2020 年 7 月至 9 月期间，共招募了 90 名青少年。平均（SD）年龄为 17.6（1.1）岁。其中一半（=45）为 YMSM。46 名（51%）为首次进行 HIV 检测者，32 名（36%）曾“使用过”HIV 暴露前预防（PrEP）。有 2 名（2.2%，95%CI：0.0-5.3）检测结果阳性，21 名（23.4%）无效，67 名（74.4%）阴性。无效的原因包括 17 名（81%）血液不足、3 名（14%）缓冲液溢出和 1 名（5%）操作失误；所有这些都有阴性 HIV 抗体检测结果。HIV 自我检测的可接受性为 87.8%（95%CI：81.0-94.5）。大多数（79%）更喜欢在医院而不是在家中进行 HIVST。