Ngoc Bao Vu, Majam Mohammed, Green Kimberly, Tran Ton, Hung Minh Tran, Que Anh Luong, Ngoc Diep Bui, Le Duy Chuong Hoang
PATH, Hanoi, Vietnam.
Ezintsha, Wits Health Consortium, University of the Witwatersrand, Johannesburg, South Africa.
PLOS Glob Public Health. 2023 Feb 1;3(2):e0001438. doi: 10.1371/journal.pgph.0001438. eCollection 2023.
HIV self-testing (HIVST) is an effective approach to increase testing uptake. While oral fluid-based HIVST has been rapidly scaled, use of blood-based HIVST remains limited. We evaluated the acceptability, feasibility, and accuracy of blood-based HIVST among lay users in Ho Chi Minh City (HCMC), Vietnam. We conducted a cross-sectional study among HIV testing clients at the HCMC Pasteur Institute from March 2019 to October 2020. Participants received one HIVST kit and performed the test in front of an observer. The observer used product-specific questionnaires to collect information on the HIVST process, test results, experiences. The participants' interpretations of HIVST results were compared to health staff's interpretations and gold standard laboratory EIA reference tests. Of 2,399 participants who accepted HIVST, 64.7% were men, 62.1% aged 25-49 years, 53.5% had a higher education level, 41.4% were employed, and 35.6% were first-time testers. The vast majority (94.4%) desired to use the test in the future, and 93.9% reported willingness to recommend the test. The majority (90.8%) of participants successfully completed the self-test. One factor associated with successful completion was higher education level (aOR = 1.85; 95% CI: 1.32-2.61); while participants self-testing with SURE CHECK (aOR = 0.21; 95% CI: 0.12-0.37), INSTI (aOR = 0.23; 95% CI: 0.13-0.39), and BioSURE (aOR = 0.29; 95% CI: 0.17-0.51) or being unemployed, retired, or doing housework (aOR = 0.45; 95% CI: 0.25-0.82) were less likely to perform the test successfully. Agreement of positive and negative HIVST results as interpreted by participants and health staff was high (98.1% and 99.9%, respectively). Sensitivity and specificity of the evaluated HIVST were 96.43% (95% CI: 93.62-99.23) and 99.9% (95% CI: 99.75-100), respectively. Our findings confirm that blood-based HIVST is highly acceptable, feasible, and accurate. This evidence informs scale-up of HIVST to increase uptake of essential HIV prevention and treatment services.
艾滋病毒自我检测（HIVST）是提高检测接受度的有效方法。虽然基于口腔液的HIVST已迅速推广，但基于血液的HIVST的使用仍然有限。我们评估了越南胡志明市（HCMC）普通用户中基于血液的HIVST的可接受性、可行性和准确性。2019年3月至2020年10月，我们在胡志明市巴斯德研究所的艾滋病毒检测客户中进行了一项横断面研究。参与者收到一套HIVST试剂盒，并在一名观察者面前进行检测。观察者使用特定产品的问卷收集有关HIVST过程、检测结果、体验的信息。将参与者对HIVST结果的解读与卫生工作人员的解读以及金标准实验室酶免疫分析参考检测进行比较。在2399名接受HIVST的参与者中，64.7%为男性，62.1%年龄在25至49岁之间，53.5%具有高等教育水平，41.4%就业，35.6%为首次检测者。绝大多数（94.4%）希望未来使用该检测，93.9%表示愿意推荐该检测。大多数（90.8%）参与者成功完成了自我检测。与成功完成检测相关的一个因素是高等教育水平（调整后的比值比[aOR]=1.85；95%置信区间[CI]：1.32-2.61）；而使用SURE CHECK（aOR=0.21；95%CI：0.12-0.37）、INSTI（aOR=0.23；95%CI：0.13-0.39）和BioSURE（aOR=0.29；95%CI：0.17-0.51）进行自我检测的参与者，或失业、退休或做家务的参与者（aOR=0.45；95%CI：
