From the Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center.
Plast Reconstr Surg. 2021 May 1;147(5):1035-1044. doi: 10.1097/PRS.0000000000007827.
Time and motion studies provide a reliable methodology to quantify efficiency and establish recommendations for best practices in autologous fat grafting. The purpose of this study was to compare the rate of graft processing of three frequently used systems for graft preparation.
The authors conducted a prospective randomized comparison of three methods to prepare adipose tissue for autologous fat grafting: an active filtration system (Revolve; LifeCell Corporation, Branchburg, N.J.), a passive filtration system (PureGraft 250; Cytori Therapeutics, San Diego, Calif.), and centrifugation. An independent observer collected data according to the study's behavioral checklist. The primary outcome measure was rate of adipose tissue processed.
Forty-six patients (mean age, 54 years; mean body mass index, 28.6 kg/m2) were included in the study (15 per arm; one patient was included with intention to treat after a failed screening). The rate of adipose tissue preparation was greater for the active filtration system compared with the others (active filtration: 9.98 ml/min versus passive filtration: 5.66 ml/min versus centrifugation: 2.47 ml/min). Similarly, there was a significant difference in total grafting time (active: 82.7 ± 8.51 minutes versus passive: 152 ± 13.1 minutes, p = 0.0005; versus centrifugation: 209.9 ± 28.5 minutes, p = 0.0005); however, there was no difference in total operative time (p = 0.82, 0.60).
As the number of fat grafting procedures increases, there is interest in developing techniques to harvest, process, and inject fat to improve clinical outcomes and operative efficiency. The results of this study indicate that an active fat processing system is more time efficient at graft preparation than a passive system or centrifugation.
时间和动作研究为量化效率并为自体脂肪移植的最佳实践建立建议提供了可靠的方法。本研究的目的是比较三种常用于脂肪组织准备的系统的移植物处理速度。
作者对三种方法进行了前瞻性随机比较，以准备用于自体脂肪移植的脂肪组织：主动过滤系统（Revolve；LifeCell 公司，新泽西州布兰奇堡）、被动过滤系统（PureGraft 250；Cytori Therapeutics，加利福尼亚州圣地亚哥）和离心。一位独立观察者根据研究的行为检查表收集数据。主要观察指标是处理脂肪组织的速度。
46 名患者（平均年龄 54 岁；平均体重指数 28.6kg/m2）纳入研究（每组 15 例；一名患者因筛选失败后进行意向治疗而被纳入）。与其他两种方法相比，主动过滤系统的脂肪组织制备速度更快（主动过滤：9.98ml/min 与被动过滤：5.66ml/min 与离心：2.47ml/min）。同样，总移植时间也有显著差异（主动：82.7±8.51 分钟与被动：152±13.1 分钟，p=0.0005；与离心：209.9±28.5 分钟，p=0.0005）；但总手术时间无差异（p=0.82，0.60）。
随着脂肪移植手术数量的增加，人们有兴趣开发技术来收获、处理和注射脂肪，以改善临床结果和手术效率。本研究的结果表明，主动脂肪处理系统在移植物准备方面比被动系统或离心更有效率。
