van Deelen G W, Ruding P R, Smoorenburg G F, Veldman J E, Huizing E H
Department of Otorhinolaryngology, University Hospital, Utrecht, The Netherlands.
Acta Otolaryngol. 1988 Mar-Apr;105(3-4):193-201. doi: 10.3109/00016488809096998.
The relation between electrocochleographic and histological changes in experimental endolymphatic hydrops was studied 1, 2, 4, or 8 months after obliteration of the endolymphatic sac. An increase in the compound Action Potential (AP) threshold was found 2, 4, and 8 months after obliteration. This increase was strongly correlated with loss of outer hair cells, nerve fibres and spiral ganglion cells. An enhanced negative Summating Potential (SP) and an enhanced SP-AP ratio were found mainly in animals with an endolymphatic hydrops without further cochlear pathology. A normal or decreased SP and SP-AP ratio was regularly recorded in animals with both an endolymphatic hydrops and a variety of other histopathological changes in the inner ear. An increased second peak (N2) in the AP waveform was recorded from 63% (15/24) of the hydropic ears, equally divided over the four groups. There was no obvious correlation between the increased N2 and other electrophysiological or histological findings.
在内淋巴囊闭塞后1、2、4或8个月，研究了实验性内淋巴积水时电耳蜗图与组织学变化之间的关系。在内淋巴囊闭塞后2、4和8个月发现复合动作电位（AP）阈值升高。这种升高与外毛细胞、神经纤维和螺旋神经节细胞的丢失密切相关。增强的负和电位（SP）和增强的SP-AP比值主要在有内淋巴积水但无进一步耳蜗病变的动物中发现。在内淋巴积水且内耳有多种其他组织病理学变化的动物中，通常记录到正常或降低的SP和SP-AP比值。从63%（15/24）的积水耳记录到AP波形中的第二个峰值（N2）增加，这在四组中分布均匀。N2增加与其他电生理或组织学结果之间没有明显的相关性。
