Nyström C, Matousek M, Hällström T
Department of Psychiatry, Sahlgren Hospital, University of Gothenburg, Sweden.
Acta Psychiatr Scand. 1988 Apr;77(4):457-62. doi: 10.1111/j.1600-0447.1988.tb05151.x.
Twenty-five patients with major depressive disorder according to RDC were examined with computerized quantitative EEG before antidepressive treatment. Normal EEGs were found in 20 patients and slight abnormality in five cases. Relationships between various EEG variables and pretreatment accumulation rate of 14C-5-HT and 3H-NA in rat synaptosomes, incubated in patients' plasma, and 5-HT in whole blood were studied. Age and current treatment with benzodiazepines were taken into account. There was an inverse relationship between alpha-1 amplitude in all derivations and beta-2 amplitude in the parieto-occipital derivation on one hand and pretreatment 14C-5-HT synaptosomal accumulation rate on the other. This result indicates that low 14C-5-HT synaptosomal accumulation rate is related to increased EEG alertness. This EEG pattern is suggested to be associated with a serotonergic subgroup of depression. The relationships between the other biochemical variables and the EEG patterns did not show any consistent pattern.
根据研究诊断标准（RDC）确诊的25例重度抑郁症患者在进行抗抑郁治疗前接受了计算机化定量脑电图检查。20例患者脑电图正常，5例有轻微异常。研究了患者血浆孵育的大鼠突触体中各种脑电图变量与14C-5-羟色胺（5-HT）、3H-去甲肾上腺素（NA）的预处理累积率以及全血中5-HT之间的关系。同时考虑了年龄和当前使用苯二氮䓬类药物的情况。一方面，所有导联的α-1波幅与顶枕导联的β-2波幅之间存在负相关，另一方面，与预处理14C-5-HT突触体累积率之间也存在负相关。这一结果表明，低14C-5-HT突触体累积率与脑电图警觉性增加有关。这种脑电图模式被认为与抑郁症的一个血清素能亚组有关。其他生化变量与脑电图模式之间的关系未显示出任何一致的模式。
