CIP2A 的耗竭抑制了神经胶质瘤细胞的增殖、迁移、侵袭和上皮-间充质转化。
Depletion of CIP2A inhibits the proliferation, migration, invasion and epithelial-mesenchymal transition of glioma cells.
机构信息
Department of Neurosurgery, The second Affiliated Hospital of Kunming Medical University, Kunming, 650223, China; Department of Neurosurgery, The Pu'er People's Hospital, Pu'er, 665000, China.
Department of Neurosurgery, The second Affiliated Hospital of Kunming Medical University, Kunming, 650223, China; Department of Neurosurgery, The Pu'er People's Hospital, Pu'er, 665000, China.
出版信息
Brain Res Bull. 2021 Aug;173:14-21. doi: 10.1016/j.brainresbull.2021.04.009. Epub 2021 Apr 20.
CIP2A is an oncoprotein that is overexpressed in multiple solid tumours and some malignant haematologic disorders. However, its function in glioma is poorly understood. In this study, our results demonstrated that the expression of CIP2A was higher in glioma tissues than in normal tissues. Using tissue microarrays for immunohistochemistry, we found that the intensity of CIP2A expression was higher in high-grade gliomas (grade III-IV) than in low-grade gliomas (grade I-II). In addition, we found that depletion of CIP2A inhibited glioma cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro. Taken together, our findings revealed that CIP2A was involved in glioma progression, indicating that CIP2A could be used as a potential therapeutic target in the future.
CIP2A 是一种癌蛋白，在多种实体肿瘤和一些恶性血液病中过度表达。然而，其在神经胶质瘤中的功能知之甚少。在这项研究中，我们的结果表明 CIP2A 在神经胶质瘤组织中的表达高于正常组织。通过组织微阵列进行免疫组织化学分析，我们发现 CIP2A 的表达强度在高级别神经胶质瘤（III-IV 级）中高于低级别神经胶质瘤（I-II 级）。此外，我们发现 CIP2A 的耗竭抑制了体外神经胶质瘤细胞的增殖、迁移、侵袭和上皮-间充质转化（EMT）。总之，我们的研究结果表明 CIP2A 参与了神经胶质瘤的进展，表明 CIP2A 将来可能被用作一种潜在的治疗靶点。
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