Tielli Alexandra, Jullien Vincent, Pull Lauren, Bouchaud Olivier, Siriez Jean-Yves
Hôpital Robert-Debré, Service d'Accueil des Urgences pédiatriques, Assistance Publique-Hôpitaux de Paris, 48 boulevard Sérurier, 75019 Paris, France.
Groupe hospitalier Paris Seine Saint-Denis, UF de Pharmacologie, Assistance Publique-Hôpitaux de Paris, Paris, France.
Int J Antimicrob Agents. 2021 May;57(5):106347. doi: 10.1016/j.ijantimicag.2021.106347. Epub 2021 Apr 20.
At the emergency department of the Robert-Debré children's hospital in Paris, France, artenimol/piperaquine (AP) has been the first-line antimalarial treatment since September 2012. Most children receive the first dose at the hospital and return home if, after 1 hour's observation, there have been no episodes of vomiting. Here we report the case of two children, aged 11 years and 5 years, respectively, in whom the entire cumulative 3 days' treatment course combined was accidentally administered instead of just the first-day treatment dose. Serum piperaquine levels were measured between Hour 40 (H40) and Day 29 (D29) post-ingestion for the first patient, and between H17 and D7 for the second patient. Corrected QT (QTc) values were measured between H12 and D20 for the first patient and between H17 and H64 for the second patient. Despite reports of adverse electrophysiological events, AP overdose occurred without consequence on the QTc interval or clinical cardiac state in these two children.
在法国巴黎的罗伯特 - 德布雷儿童医院急诊科，自2012年9月以来，蒿甲醚/哌喹（AP）一直是一线抗疟治疗药物。大多数儿童在医院接受首剂治疗，若经过1小时观察后未出现呕吐情况，便可回家。在此，我们报告两例儿童病例，分别为11岁和5岁，他们意外接受了整个3天的累积治疗疗程，而不是仅首日治疗剂量。对首例患者，在摄入药物后第40小时（H40）至第29天（D29）期间测量血清哌喹水平；对第二例患者，在第17小时（H17）至第7天（D7）期间测量。对首例患者，在第12小时（H12）至第20天（D20）期间测量校正QT（QTc）值；对第二例患者，在第17小时（H17）至第64小时（H64）期间测量。尽管有不良电生理事件的报告，但这两名儿童发生AP过量后，QTc间期或临床心脏状态均未受到影响。
