2nd University Department of Neurology, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.
1st University Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA University Hospital, Greece.
Clin Neurol Neurosurg. 2021 Jun;205:106625. doi: 10.1016/j.clineuro.2021.106625. Epub 2021 Apr 1.
Progressive multifocal leukoencephalopathy (PML) is attributed to reactivation of the John Cunningham virus (JCV), in the central nervous system as a result of immunosuppression. Low L-selectin (CD62L) expression on cryopreserved T-cells has been advocated as a biomarker for natalizumab related PML in patients with Relapsing-Remitting Multiple Sclerosis. A rare case of PML in an elderly patient without known factors of immunosuppression or immunomodulation is hereby presented. T-cell L-selectin expression levels and serum anti-JCV antibody index were evaluated in order to explore mechanistic insight to the pathways that presumably contribute towards PML development in this rare clinical setting.
进行性多灶性白质脑病（PML）归因于中枢神经系统中约翰·坎宁安病毒（JCV）的重新激活，这是由于免疫抑制所致。冷冻保存 T 细胞上低 L-选择素（CD62L）表达已被提倡作为复发性多发性硬化症患者中与那他珠单抗相关 PML 的生物标志物。本文报告了一例老年患者发生 PML 的罕见病例，该患者无已知免疫抑制或免疫调节因素。评估了 T 细胞 L-选择素表达水平和血清抗 JCV 抗体指数，以探索可能导致这种罕见临床情况下 PML 发展的机制。
