血清和血细胞中汞的分布与自发性早产风险的关系：中国一项巢式病例对照研究。
Distribution of mercury in serum and blood cells and risk of spontaneous preterm birth: A nested case-control study in China.
机构信息
Institute of Reproductive and Child Health, Peking University, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
Institute of Geographic Sciences and Natural Resources Research, CAS, Beijing 100101, PR China.
出版信息
Ecotoxicol Environ Saf. 2021 Jul 1;217:112228. doi: 10.1016/j.ecoenv.2021.112228. Epub 2021 Apr 20.
The relationship between maternal mercury (Hg) intake and the risk of spontaneous preterm birth (SPB) remains unclear. We conducted a nested case-control study from a prospective cohort in Shanxi Province, China, to explore their associations. In total, 126 pregnant women with SPB (cases) and 348 controls with term delivery were included. We measured the Hg concentrations in their serum (Hg) and blood cell (Hg) fractions and calculated the concentration ratio of Hg in serum to Hg in blood cells (Hg). We found that only the Hg in the case group was slightly higher than that in control group. The OR of Hg associated with SPB risk was 1.57 [95%CI: 0.99-2.46] with adjusting confounders. After stratification by sampling time, the association above was only statistically significant in the first trimester. High Hg may increase the risk of SPB in the first trimester among women with relatively low Hg exposure.
母体汞（Hg）摄入与自发性早产（SPB）风险之间的关系尚不清楚。我们在中国山西省进行了一项嵌套病例对照研究，以探讨它们之间的关联。共纳入 126 例 SPB 孕妇（病例组）和 348 例足月分娩孕妇（对照组）。我们测量了她们血清（Hg）和血细胞（Hg）中 Hg 的浓度，并计算了血清中 Hg 与血细胞中 Hg 的浓度比（Hg）。我们发现，只有病例组的 Hg 略高于对照组。调整混杂因素后，Hg 与 SPB 风险的 OR 为 1.57[95%CI：0.99-2.46]。按采样时间分层后，上述关联仅在孕早期具有统计学意义。在 Hg 暴露相对较低的孕妇中，高 Hg 可能会增加孕早期 SPB 的风险。
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