古菌特有蛋白家族对真核生物共同祖先的贡献为 0.3。
The Asgard Archaeal-Unique Contribution to Protein Families of the Eukaryotic Common Ancestor Was 0.3.
机构信息
Institute for Molecular Evolution, Heinrich-Heine-University Düsseldorf, Germany.
Centre for Organelle Research, University of Stavanger, Norway.
出版信息
Genome Biol Evol. 2021 Jun 8;13(6). doi: 10.1093/gbe/evab085.
The identification of the asgard archaea has fueled speculations regarding the nature of the archaeal host in eukaryogenesis and its level of complexity prior to endosymbiosis. Here, we analyzed the coding capacity of 150 eukaryotes, 1,000 bacteria, and 226 archaea, including the only cultured member of the asgard archaea. Clustering methods that consistently recover endosymbiotic contributions to eukaryotic genomes recover an asgard archaeal-unique contribution of a mere 0.3% to protein families present in the last eukaryotic common ancestor, while simultaneously suggesting that this group's diversity rivals that of all other archaea combined. The number of homologs shared exclusively between asgard archaea and eukaryotes is only 27 on average. This tiny asgard archaeal-unique contribution to the root of eukaryotic protein families questions claims that archaea evolved complexity prior to eukaryogenesis. Genomic and cellular complexity remains a eukaryote-specific feature and is best understood as the archaeal host's solution to housing an endosymbiont.
古菌 Asgard 的鉴定引发了人们对于真核生物起源过程中古菌宿主的本质及其在共生之前的复杂程度的猜测。在这里,我们分析了 150 种真核生物、1000 种细菌和 226 种古菌的编码能力,其中包括唯一培养的 Asgard 古菌成员。聚类方法一致地恢复了内共生对真核生物基因组的贡献,结果表明,在最后一个真核生物共同祖先中存在的蛋白质家族中,Asgard 古菌的独特贡献仅为 0.3%,同时表明该组的多样性可与所有其他古菌相媲美。Asgard 古菌和真核生物之间独有的同源物数量平均只有 27 个。这种在真核生物蛋白质家族根部的古菌 Asgard 独特的微小贡献质疑了古菌在真核生物起源之前进化出复杂性的说法。基因组和细胞的复杂性仍然是真核生物特有的特征,最好将其理解为古菌宿主为容纳内共生体而采取的解决方案。