Schlöndorff Johannes S
Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Kidney Int. 2021 May;99(5):1065-1067. doi: 10.1016/j.kint.2021.01.006.
Genetics contributes significantly to the development of kidney diseases. In the case of glomerular diseases such as focal segmental glomerulosclerosis, over a dozen genes involved in maintaining and regulating the actin cytoskeleton of podocytes have been implicated. A new study adds the atypical myosin, MYO9A, to that list using a combination of human and mouse genetics, suggesting a link to enhanced RhoA activity. Unraveling the growing web of actin regulators remains a key challenge to understanding podocytopathies.
遗传学在肾脏疾病的发展中起着重要作用。在局灶节段性肾小球硬化等肾小球疾病中，已有十几个参与维持和调节足细胞肌动蛋白细胞骨架的基因被牵连。一项新研究通过结合人类和小鼠遗传学方法，将非典型肌球蛋白MYO9A列入该名单，提示其与RhoA活性增强有关。理清不断增加的肌动蛋白调节因子网络仍然是理解足细胞病的关键挑战。
