Inserm U-1018, Centre de recherche en épidémiologie et santé des populations (CESP), Paris-Ile-de-France-Ouest University, Paris-Sud University, and Paris Saclay University, Villejuif, France.
Department of Nephrology and Clinical Immunology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany.
Kidney Int. 2021 May;99(5):1070-1072. doi: 10.1016/j.kint.2021.01.019.
In chronic kidney disease, parathyroid hormone (PTH), like all proteins, can undergo post-translational modifications, including oxidation. This can lead to structural and functional changes of the hormone. It has been hypothesized that currently used PTH measurement methods do not adequately reflect PTH-related bone and cardiovascular abnormalities in chronic kidney disease owing to the presence of oxidized, biologically inactive PTH in the circulation. Ursem et al. now report a strong correlation between serum non-oxidized and total PTH, and comparable associations with histomorphometric and circulating bone turnover markers, pleading against this hypothesis.
在慢性肾病中，甲状旁腺激素（PTH）与所有蛋白质一样，可以进行翻译后修饰，包括氧化。这可能导致激素的结构和功能发生变化。有人假设，由于循环中存在氧化的、无生物活性的 PTH，目前使用的 PTH 测量方法不能充分反映慢性肾脏病中与 PTH 相关的骨骼和心血管异常。Ursem 等人现在报告血清中非氧化和总 PTH 之间具有很强的相关性，并且与组织形态计量学和循环骨转换标志物具有可比性的相关性，从而反驳了这一假设。
