滑膜肉瘤发生机制的单细胞解析。
Synovial Sarcoma Oncogenesis Revealed by Single-Cell Profiling.
机构信息
Faculty of Medicine, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.
Faculty of Medicine, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.
出版信息
Trends Cancer. 2021 Jun;7(6):482-483. doi: 10.1016/j.trecan.2021.03.002. Epub 2021 Apr 21.
Synovial sarcoma is a soft tissue malignancy driven by the SS18-SSX fusion oncoprotein. In Nature Medicine, Jerby-Arnon et al. present a single-cell dataset for synovial sarcoma that reveals a novel 'core oncogenic program' driven by SS18-SSX, with implications for treatment strategies based on epigenetics, cell-cycle control, and immune augmentation.
滑膜肉瘤是一种由 SS18-SSX 融合癌蛋白驱动的软组织恶性肿瘤。在《自然医学》杂志上，Jerby-Arnon 等人发表了一份滑膜肉瘤的单细胞数据集，揭示了一种由 SS18-SSX 驱动的新型“核心致癌程序”，这对基于表观遗传学、细胞周期控制和免疫增强的治疗策略具有重要意义。
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