Jin Xin, Huang Lin, Wang Xueyan, Tan Yun, Huang Miao, Fu Haijing, Wen Chengping, Zhou Mingqian
Key Laboratory of Chinese medicine rheumatology of Zhejiang Province, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, China.
School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, China.
J Orthop Translat. 2025 Jul 16;54:26-36. doi: 10.1016/j.jot.2025.07.004. eCollection 2025 Sep.
As an emerging three-dimensional (3D) cell culture model, synovial organoids can highly mimic the structure and function of synovial tissue in vivo, providing a new and powerful tool for the research of synovial-related diseases. This article elaborated in detail on the construction of synovial organoids from the cell sources, culture systems, and construction techniques. Meanwhile, it comprehensively reviewed the application progress of synovial organoids in arthritic diseases including rheumatoid arthritis and osteoarthritis such as disease pathogenesis, drug development, and personalized therapy. Additionally, it explores current challenges and future directions for synovial organoids, providing a reference for further research and applications in related-diseases. The Translational Potential of this Article Synovial organoids enable direct modeling of the human synovial joint, offering a physiologically relevant platform for high-throughput drug screening. Patient-derived organoids not only facilitate the development of personalized medicine but also reduce reliance on animal studies for preclinical validation. This approach addresses ethical challenges and species-specific limitations while enhancing the translational relevance to human disease mechanisms.
作为一种新兴的三维（3D）细胞培养模型，滑膜类器官能够高度模拟体内滑膜组织的结构和功能，为滑膜相关疾病的研究提供了一种全新且强大的工具。本文从细胞来源、培养体系和构建技术等方面详细阐述了滑膜类器官的构建过程。同时，全面综述了滑膜类器官在类风湿关节炎和骨关节炎等关节炎疾病中的应用进展，包括疾病发病机制、药物研发和个性化治疗等方面。此外，探讨了滑膜类器官目前面临的挑战和未来发展方向，为相关疾病的进一步研究和应用提供参考。本文的转化潜力 滑膜类器官能够直接构建人体滑膜关节模型，为高通量药物筛选提供一个生理相关的平台。患者来源的类器官不仅有助于个性化医疗的发展，还能减少临床前验证对动物研究的依赖。这种方法解决了伦理挑战和物种特异性限制，同时增强了与人类疾病机制的转化相关性。
