Department of General Medicine, AIIMS Rishikesh, Rishikesh, Uttarakhand, India.
Department of Medical Oncology Haematology, All India Institute of Medical Sciences-Rishikesh, Rishikesh, Uttarakhand, India.
BMJ Case Rep. 2021 Apr 23;14(4):e242683. doi: 10.1136/bcr-2021-242683.
While lymphopenia has been a common finding in COVID-19 infection, particularly in severe cases, febrile neutropenia has been very rarely reported in immunocompetent patients with COVID-19. Herein, we report the case of a 76-year-old hypertensive and diabetic man who was hospitalised with severe COVID-19 infection and developed delayed-onset severe neutropenia with neutropenic fever, which responded to treatment with antibiotics and granulocyte colony-stimulating factor. This case highlights the importance of identifying a rare complication (febrile neutropenia on the fifth week) of COVID-19 infection in hospitalised patients by intensive monitoring and aggressive management for favourable outcomes.
虽然淋巴细胞减少在 COVID-19 感染中很常见,尤其是在重症病例中,但免疫功能正常的 COVID-19 患者中很少有发热性中性粒细胞减少症的报道。在此,我们报告了一例 76 岁的高血压和糖尿病男性患者,因严重 COVID-19 感染住院,并发生迟发性严重中性粒细胞减少伴中性粒细胞减少性发热,经抗生素和粒细胞集落刺激因子治疗后有所缓解。该病例强调了通过强化监测和积极管理,以获得有利的结果,识别住院患者 COVID-19 感染罕见并发症(第五周发热性中性粒细胞减少症)的重要性。