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PSMA 抑制剂 18F-DCFPyL-PET-CT 图像对前列腺癌的诊断准确率如何?

How Accurately does PSMA Inhibitor 18F-DCFPyL-PET-CT Image Prostate Cancer?

机构信息

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.

Department of Radiology, Molecular Imaging, Seattle Cancer Care Alliance, and Nuclear Medicine, University of Washington, Seattle, Washington.

出版信息

Clin Cancer Res. 2021 Jul 1;27(13):3512-3514. doi: 10.1158/1078-0432.CCR-21-0749. Epub 2021 Apr 23.

Abstract

Current techniques for imaging prostate cancer (CT, MRI, and PET agents F-fluorodeoxyglucose, C-choline, C-acetate, and F-fluciclovine) are limited in sensitivity and specificity. PSMA PET agent Ga-PSMA-11 has recently been approved by the FDA. We comment on the performance of novel PSMA agent 18F-DCFPyL-PET/CT..

摘要

当前用于诊断前列腺癌的影像学技术(CT、MRI 和 PET 探针 F-氟代脱氧葡萄糖、C-胆碱、C-乙酸和 F-氟代赖氨酸)的敏感性和特异性均有限。PSMA PET 探针 Ga-PSMA-11 最近已获得 FDA 批准。我们对新型 PSMA 探针 18F-DCFPyL-PET/CT 的性能进行了评价。

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