Wapnir R A, Zdanowicz M M, Teichberg S, Lifshitz F
Department of Pediatrics, North Shore University Hospital, Manhasset, NY 11030.
Am J Clin Nutr. 1988 Jul;48(1):84-90. doi: 10.1093/ajcn/48.1.84.
Improvement of sodium absorption during the administration of oral hydration solutions (OHS) could increase the efficacy of formulations used in the treatment of infantile diarrhea. To test this hypothesis, selected protein breakdown products were evaluated as absorption enhancers in OHS of different osmolalities and Na-to-glucose ratios in an animal model of osmotic diarrhea induced by cathartics. A very significant increase in water and Na absorption occurred in rats with diarrhea when they were perfused with a 90-mmol/L-Na, 111-mmol/L-glucose OHS containing 30 mmol/L of L-alanine (Ala). The same effect on Na retention was observed with a protein hydrolysate (PrH) in rats with diarrhea. Glycine was not effective. Other experimental OHS were ineffective in rats with diarrhea. The data indicate that in this animal model of chronic diarrhea Na transport enhancers, such as Ala and a PrH, are most efficacious in the presence of higher Na concentration.
在口服补液溶液（OHS）给药期间提高钠吸收可增强用于治疗婴儿腹泻的制剂的疗效。为验证这一假设，在一种由泻药诱发的渗透性腹泻动物模型中，对不同渗透压和钠糖比的OHS中选定的蛋白质分解产物作为吸收促进剂进行了评估。当用含有30 mmol/L L-丙氨酸（Ala）的90 mmol/L钠、111 mmol/L葡萄糖的OHS灌注腹泻大鼠时，水和钠的吸收显著增加。在腹泻大鼠中，蛋白质水解物（PrH）对钠潴留也有相同作用。甘氨酸无效。其他实验性OHS对腹泻大鼠无效。数据表明，在这种慢性腹泻动物模型中，诸如Ala和PrH等钠转运增强剂在较高钠浓度存在时最为有效。
