Department of Pathobiology and Population Sciences and London Centre for Neglected Tropical Disease Research, Royal Veterinary College, Hatfield, United Kingdom.
MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology and London Centre for Neglected Tropical Disease Research, Imperial College London, London, United Kingdom.
Clin Infect Dis. 2021 Sep 15;73(6):e1391-e1396. doi: 10.1093/cid/ciab350.
Drug-based interventions are at the heart of global efforts to reach elimination as a public health problem (trachoma, soil-transmitted helminthiases, schistosomiasis, lymphatic filariasis) or elimination of transmission (onchocerciasis) for 5 of the most prevalent neglected tropical diseases tackled via the World Health Organization preventive chemotherapy strategy. While for some of these diseases there is optimism that currently available drugs will be sufficient to achieve the proposed elimination goals, for others-particularly onchocerciasis-there is a growing consensus that novel therapeutic options will be needed. Since in this area no high return of investment is possible, minimizing wasted money and resources is essential. Here, we use illustrative results to show how mathematical modeling can guide the drug development pathway, yielding resource-saving and efficiency payoffs, from the refinement of target product profiles and intended context of use to the design of clinical trials.
药物干预是全球努力消除公共卫生问题（沙眼、土源性蠕虫病、血吸虫病、淋巴丝虫病）或消除传播（盘尾丝虫病）的核心，这是通过世界卫生组织预防性化疗战略来解决的 5 种最常见的被忽视热带病。虽然对于其中一些疾病，人们乐观地认为现有的药物将足以实现拟议的消除目标，但对于其他疾病，特别是盘尾丝虫病，人们越来越一致认为需要新的治疗选择。由于在这一领域不可能有高投资回报，因此尽量减少浪费的资金和资源至关重要。在这里，我们使用说明性结果来展示数学建模如何指导药物开发途径，从目标产品概况的细化和预期使用背景到临床试验的设计，实现节省资源和提高效率的回报。
