Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Department of Oral and Maxillofacial Surgery and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
Head Neck. 2021 Aug;43(8):2457-2467. doi: 10.1002/hed.26712. Epub 2021 Apr 24.
It has been reported in oral squamous cell carcinoma (OSCC) that myeloid-derived suppressor cells infiltrate tumor tissues. This study examined whether S-1 chemotherapy changes immune cell populations in the tumor microenvironment.
We examined 71 patients with of OSCC, including 51 patients who received preoperative S-1 chemotherapy. Immunohistochemistry for PD-L1, CD8, forkhead box protein 3 (FOXP3), and CD15 was performed using biopsy and resected specimens.
The numbers of CD8 , FOXP3 , and CD15 cells in resected specimens were significantly decreased by S-1 chemotherapy. The reduction of the proportion of CD15 cells significantly differed between responders and nonresponders. Most responders were distributed into the group with low PD-L1 expression and a low density of CD8 cells before chemotherapy. Furthermore, many patients with recurrence exhibited a high density of CD15 cells in biopsy specimens.
Preoperative S-1 chemotherapy can potentially improve prognosis by reducing CD15 cells in the tumor microenvironment.
已有报道称，髓系来源的抑制细胞浸润口腔鳞状细胞癌（OSCC）肿瘤组织。本研究旨在探讨替吉奥化疗是否会改变肿瘤微环境中的免疫细胞群体。
我们对 71 例 OSCC 患者进行了研究，其中 51 例患者在术前接受了替吉奥化疗。使用活检和切除标本进行 PD-L1、CD8、叉头框蛋白 3（FOXP3）和 CD15 的免疫组织化学染色。
替吉奥化疗显著减少了切除标本中 CD8、FOXP3 和 CD15 细胞的数量。化疗后 CD15 细胞比例的降低在应答者和非应答者之间有显著差异。大多数应答者在化疗前被分为 PD-L1 表达低和 CD8 细胞密度低的组。此外，许多复发患者在活检标本中表现出 CD15 细胞密度较高。
术前替吉奥化疗可能通过减少肿瘤微环境中的 CD15 细胞来改善预后。
