Bowers E J, Mayro R F, Whitaker L A, Pasquariello P S, Larossa D, Randall P
Facial Reconstruction Center, Childrens Hospital of Philadelphia, Pennsylvania 19104.
Am J Phys Anthropol. 1988 Apr;75(4):503-15. doi: 10.1002/ajpa.1330750408.
Clefts of the lip and palate, separately or in combination, are among the most frequent congenital defects seen today. Their etiology is heterogeneous and may include hormonal factors, which suggest the possibility of growth effects. Whether affected children are smaller than others has not been determined. We recently showed that growth status is associated with type of cleft. We hypothesized genetic alterations in metabolic pathways that alter prenatal growth, producing clefts; some of these alterations also alter postnatal growth. Since the levels of growth-regulating hormones change during ontogeny, we expected age differences in the degree of growth deficit seen. To test this hypothesis, we examine here the cross-sectional means and distributions of standard deviation (z) scores for height and body mass indices (BMIs) for 144 children with the diagnoses unilateral cleft lip and palate (uCLP) and isolated cleft palate (iCP). We find that alteration in growth status is associated with age group as well as sex and diagnosis.
唇腭裂单独或合并出现，是当今最常见的先天性缺陷之一。其病因具有异质性，可能包括激素因素，这提示了生长效应的可能性。受影响的儿童是否比其他儿童体型更小尚未确定。我们最近表明，生长状况与腭裂类型有关。我们推测，代谢途径中的基因改变会改变产前生长，导致腭裂；其中一些改变也会改变产后生长。由于生长调节激素的水平在个体发育过程中会发生变化，我们预计会出现年龄差异导致的生长缺陷程度不同。为了验证这一假设，我们在此研究了144例诊断为单侧唇腭裂（uCLP）和单纯腭裂（iCP）儿童的身高和体重指数（BMI）的横断面均值以及标准差（z）评分分布。我们发现，生长状况的改变与年龄组、性别和诊断有关。
