代谢紊乱与骨组织矿物质密度在骨坏死早期发病机制中的作用：激素诱导性骨坏死兔模型研究。
Metabolic Disorders and Mineral Density of the Bone Tissue in the Early Pathogenesis of Osteonecrosis: Study on Rabbits with Steroid-Induced Osteonecrosis.
机构信息
Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, China.
Faculty of Health Sciences, University of Macau, Macau, China.
出版信息
Bull Exp Biol Med. 2021 Apr;170(6):724-728. doi: 10.1007/s10517-021-05141-3. Epub 2021 Apr 24.
Abstract
The relationship between the appearance of bone metabolism disorders and the onset of steroid-induced osteonecrosis remains unclear. We studied the time course of calcium, phosphorus, osteocalcin, alkaline phosphatase, and mineral density of bone tissue in the subchondral bone of the femoral head of rabbits injected with steroids and attempted to precisely determine the time when disorders in bone metabolism started in animals with steroid-induced osteonecrosis. We detected bone metabolism disorders involved in the early pathogenesis of steroid-induced osteonecrosis, which were the cause, but not the result of this condition.
摘要
骨代谢紊乱的出现与类固醇诱导性骨坏死的发病之间的关系尚不清楚。我们研究了注射类固醇的兔股骨头软骨下骨的钙、磷、骨钙素、碱性磷酸酶和骨组织矿物质密度的时间过程，并试图准确确定类固醇诱导性骨坏死动物中骨代谢紊乱开始的时间。我们检测到类固醇诱导性骨坏死早期发病机制中涉及的骨代谢紊乱，这些紊乱是该疾病的原因，而不是结果。
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