University of South-Eastern Norway, Drammen, Norway.
Norwegian Radiation and Nuclear Safety Authority (DSA), Østerås, Norway.
Photochem Photobiol Sci. 2021 May;20(5):615-625. doi: 10.1007/s43630-021-00043-9. Epub 2021 Apr 24.
Advocates of skin protection against blue light express concern about exposure to indoor lighting and electronic screens as well as natural outdoor exposure. However, the nature of adverse effects in skin is unclear and the doses to induce effects are unknown. We aimed to reveal whether there is a scientific basis for promoting skin protection against violet-blue light (400-500 nm, VBL). Based on published literature, we determined the time to reach a threshold dose that induced a biological response in human skin. In the absence of an action spectrum for effects on skin, we used a hand held probe with a defined spectral response and measurements of the unweighted exposure between 400 and 500 nm to estimate the exposure by a selection of artificial light sources and solar light. For comparison, an outdoor threshold erythemally weighted UV dose was set to 1 SED (standard erythema dose). Outdoor, weighted irradiances were obtained using a radiative transfer model. Induction of pigmentation in human skin tissue was the only consistently reported endpoint after VBL exposure of about 65 Jcm. This threshold dose was reached in 0.5 to 20 months of exposure to indoor lighting sources. In comparison, specialised medical sources reached this dose in 0.5 min to 45 h. The time outdoors to reach 1 SED was shorter than the time to reach a VBL threshold dose throughout all seasons. Skin protection against VBL is superfluous for exposures to domestic lighting sources or screens and for solar radiation; however, it may be advantageous for patients suffering from photosensitive diseases or taking photosensitising medication.
蓝光防护倡导者对室内照明和电子屏幕以及自然户外暴露所带来的蓝光暴露表示担忧。然而，皮肤不良反应的性质尚不清楚，诱导效应的剂量也未知。我们旨在揭示推广皮肤对紫-蓝光（400-500nm，VBL）防护是否有科学依据。基于已发表的文献，我们确定了达到诱导人体皮肤生物学反应的阈值剂量所需的时间。由于缺乏对皮肤影响的作用光谱，我们使用具有定义光谱响应的手持式探头和 400 至 500nm 之间的未加权暴露测量来估计各种人工光源和太阳光的暴露。为了进行比较，设定了一个户外红斑加权紫外线剂量（SED）为 1。使用辐射传输模型获得户外加权辐照度。在 VBL 暴露约 65Jcm 后，只有色素沉着的诱导被一致报道为唯一的终点。达到这个阈值剂量需要 0.5 到 20 个月的室内光源暴露。相比之下，专门的医疗源在 0.5 分钟到 45 小时内达到这个剂量。在所有季节，达到 1SED 的户外时间都短于达到 VBL 阈值剂量的时间。对于室内照明源或屏幕以及太阳辐射的暴露，皮肤对 VBL 的防护是多余的；然而，对于患有光敏性疾病或服用光致敏药物的患者来说，它可能是有益的。
