School of Life Science, Shanghai University, Shanghai, China.
School of Life Science, Shanghai University, Shanghai, China.
Behav Brain Res. 2021 Jul 9;409:113314. doi: 10.1016/j.bbr.2021.113314. Epub 2021 Apr 21.
Cognitive decline is a common clinical symptom in Parkinson's disease (PD) patients. Fluoxetine (FLU), a selective serotonin reuptake inhibitor, can improve cognitive deficits in demented patients. The present study investigated the effects of FLU on spatial learning and memory cognitions in 6-OHDA lesioned rats. Morris water maze (MWM) test showed that FLU significantly improved spatial cognitive deficits in rats with unilateral 6-OHDA injection at 4 and 7 weeks after 6-OHDA injection. Electrophysiological recordings demonstrated that the number and duration of high voltage spindles(HVSs)in the ipsilateral hippocampus of 6-OHDA lesioned rats were decreased by the administration of FLU. Furthermore, the spectral analysis of per frequency revealed increases in δ and θ rhythm power and decreases in α, β and γ rhythm power in the ipsilateral hippocampus of 6-OHDA lesioned rats in contrast to the saline-treated rats. Acute FLU treatment can reduce δ and θ rhythm power, and enhance α, β and γ rhythm power in the ipsilateral hippocampus of 6-OHDA lesioned rats. These findings suggest that FLU improves impaired cognition by tuning oscillatory activities in the hippocampus of 6-OHDA lesioned rats.
认知衰退是帕金森病（PD）患者的常见临床症状。氟西汀（FLU），一种选择性 5-羟色胺再摄取抑制剂，可改善痴呆患者的认知缺陷。本研究探讨了 FLU 对单侧 6-OHDA 注射大鼠空间学习和记忆认知的影响。Morris 水迷宫（MWM）测试表明，FLU 可显著改善单侧 6-OHDA 注射后 4 周和 7 周大鼠的空间认知缺陷。电生理记录显示，FLU 给药可减少单侧 6-OHDA 损伤大鼠海马内同侧高电压纺锤波（HVSs）的数量和持续时间。此外，与生理盐水处理的大鼠相比，对侧海马内 δ 和 θ 节律功率增加，α、β 和 γ 节律功率降低。急性 FLU 治疗可降低对侧海马内 δ 和 θ 节律功率，增强 α、β 和 γ 节律功率。这些发现表明，FLU 通过调节 6-OHDA 损伤大鼠海马中的振荡活动来改善受损的认知。
