H65+CAF01 亚单位疫苗增强了卡介苗对牛型结核分枝杆菌感染的保护作用，在牛型结核分枝杆菌感染的小鼠模型中。
The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis.
机构信息
Instituto de Agrobiotecnología y Biología Molecular, (IABIMO) INTA-CONICET, Argentina; Instituto de Biotecnología, CICVyA, Instituto Nacional de Tecnología Agropecuaria, Institute of Biotechnology, National Institute of Agricultural Technology, Argentina.
Department of Infectious Disease Immunology, Statens Serum Institut, DK-2300 Copenhagen, Denmark.
出版信息
Res Vet Sci. 2021 May;136:595-597. doi: 10.1016/j.rvsc.2021.04.014. Epub 2021 Apr 14.
H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study, we evaluated the impact of combining BCG with H65 + CAF01 immunization in a M. bovis mouse model of infection. We found that a BCG-H65 + CAF01/ H65 + CAF01 prime-boost scheme induced higher protection than BCG and H65 + CAF01 alone. Altogether, H65 antigen formulated in liposomal adjuvant improved the BCG-induced immune protection, thus making this vaccine strategy a promising tool to control bovine tuberculosis.
H65 是由结核分枝杆菌和牛分枝杆菌的三对 ESX 分泌抗原融合而成的融合蛋白，与脂质体佐剂 CAF01 联合使用已被证明可在小鼠中预防结核分枝杆菌感染。在这项研究中，我们评估了在牛分枝杆菌感染的小鼠模型中，将卡介苗（BCG）与 H65+CAF01 免疫联合使用的影响。我们发现，BCG-H65+CAF01/H65+CAF01 初免-加强免疫方案比单独使用 BCG 和 H65+CAF01 诱导的保护作用更高。总之，脂质体佐剂中的 H65 抗原提高了卡介苗诱导的免疫保护作用，因此这种疫苗策略成为控制牛结核病的一种有前途的工具。
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