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早孕期胎儿面部轮廓标记的超声研究。

Ultrasonographic study of fetal facial profile markers during the first trimester.

机构信息

Center for Medical Ultrasound, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, No. 26 Daoqian Street, 215002, Suzhou, Jiangsu, China.

出版信息

BMC Pregnancy Childbirth. 2021 Apr 24;21(1):324. doi: 10.1186/s12884-021-03813-6.

DOI:10.1186/s12884-021-03813-6
PMID:33894762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8070329/
Abstract

BACKGROUND

To establish reference ranges of fetal facial profile markers and study their correlations with crown-rump length (CRL) during the first trimester (11 ~ 13 weeks' gestation) in a Chinese population.

METHODS

Ultrasonographic images of measuring fetal nuchal translucency (NT) were retrospectively selected randomly in normal fetuses whose parents were both Chinese. The facial markers included inferior facial angle (IFA), maxilla-nasion-mandible (MNM) angle, facial maxillary angle (FMA) and profile line (PL) distance. These markers were measured through ViewPoint 6 software by two experienced sonographers.

RESULTS

Three hundred and eighty fetuses were selected. The ICCs (95 % CI) of intra-operator 1 reproducibility of IFA, MNM angle, FMA, PL distance were 0.944 (0.886 ~ 0.973), 0.804 (0.629 ~ 0.902), 0.834 (0.68 ~ 0.918) and 0.935 (0.868 ~ 0.969), respectively. The ICCs (95 % CI) of intra-operator 2 reproducibility of IFA, MNM angle, FMA, PL distance were 0.931 (0.857 ~ 0.967), 0.809 (0.637 ~ 0.904), 0.786 (0.600 ~ 0.892) and 0.906 (0.813 ~ 0.954), respectively. The ICCs (95 % CI) of inter-operator reproducibility of IFA, MNM angle, FMA, PL distance were 0.885 (0.663 ~ 0.953), 0.829 (0.672 ~ 0.915), 0.77 (0.511 ~ 0.891) and 0.844 (0.68 ~ 0.925), respectively. The average ± SD of IFA, MNM angle, FMA and PL distance were 80.2°±7.25°, 4.17°±1.19°, 75.36°±5.31°, 2.78 ± 0.54 mm, respectively. IFA and PL distance significantly decreased with CRL, while MNM angle and FMA significantly increased with CRL.

CONCLUSIONS

It was feasible to measure fetal facial markers during the first trimester. In Chinese population, the reference ranges of IFA, MNM angle, FMA and PL distance were 80.2°±7.25°, 4.17°±1.19°, 75.36°±5.31°, 2.78 ± 0.54 mm, respectively, and the measurements were found to correlate with CRL.

摘要

背景

为了建立中国人群中胎儿面部轮廓标志的参考范围，并研究其与妊娠早期（11~13 周）头臀长（CRL）的相关性。

方法

回顾性随机选择经父母双方均为中国人的正常胎儿进行颈项透明层（NT）超声测量。面部标志包括下颌角（IFA）、上颌骨-鼻根-下颌骨（MNM）角、面部上颌骨角（FMA）和轮廓线（PL）距离。两名有经验的超声医师使用 ViewPoint 6 软件进行测量。

结果

共选择了 380 名胎儿。IFA、MNM 角、FMA 和 PL 距离的内操作员 1 可重复性的 ICC（95%CI）分别为 0.944（0.8860.973）、0.804（0.6290.902）、0.834（0.680.918）和 0.935（0.8680.969）。IFA、MNM 角、FMA 和 PL 距离的内操作员 2 可重复性的 ICC（95%CI）分别为 0.931（0.8570.967）、0.809（0.6370.904）、0.786（0.6000.892）和 0.906（0.8130.954）。IFA、MNM 角、FMA 和 PL 距离的间操作员可重复性的 ICC（95%CI）分别为 0.885（0.6630.953）、0.829（0.6720.915）、0.77（0.5110.891）和 0.844（0.680.925）。IFA、MNM 角、FMA 和 PL 距离的平均值±SD 分别为 80.2°±7.25°、4.17°±1.19°、75.36°±5.31°和 2.78±0.54mm。IFA 和 PL 距离随 CRL 显著降低，而 MNM 角和 FMA 随 CRL 显著增加。

结论

在妊娠早期测量胎儿面部标志是可行的。在中国人群中，IFA、MNM 角、FMA 和 PL 距离的参考范围分别为 80.2°±7.25°、4.17°±1.19°、75.36°±5.31°和 2.78±0.54mm，这些测量值与 CRL 相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/3448b54ce34f/12884_2021_3813_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/cae711eb6d8e/12884_2021_3813_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/cfae342dfdb4/12884_2021_3813_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/256a41c9a019/12884_2021_3813_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/c5664b35033e/12884_2021_3813_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/a697b72bee08/12884_2021_3813_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/80eeb08eac23/12884_2021_3813_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/c3a2c69da35d/12884_2021_3813_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/3448b54ce34f/12884_2021_3813_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/cae711eb6d8e/12884_2021_3813_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/cfae342dfdb4/12884_2021_3813_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/256a41c9a019/12884_2021_3813_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/c5664b35033e/12884_2021_3813_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/a697b72bee08/12884_2021_3813_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/80eeb08eac23/12884_2021_3813_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/c3a2c69da35d/12884_2021_3813_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f97c/8070329/3448b54ce34f/12884_2021_3813_Fig8_HTML.jpg

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Measurement of inferior facial angle and prefrontal space ratio in first trimester fetuses with aneuploidies: a retrospective study.测量早孕期三体胎儿的下面部角度和额前间距比：一项回顾性研究。
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Objective assessment of the fetal facial profile at second and third trimester of pregnancy.
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