骨生物标志物在个体化医学中的应用。
Osteomorphs as a tool for personalized medicine.
机构信息
Univ Angers, GEROM, SFR ICAT, F-49000 Angers, France; CHU Angers, Bone Pathology, F-49933 Angers, France.
Univ Angers, GEROM, SFR ICAT, F-49000 Angers, France.
出版信息
Trends Endocrinol Metab. 2021 Sep;32(9):655-656. doi: 10.1016/j.tem.2021.04.004. Epub 2021 Apr 22.
McDonald and colleagues reported osteoclast-related dynamic mechanisms that lead, by fission, to osteomorphs; motile, fusion-competent cells capable of forming bone-resorbing osteoclasts. scRNA-seq analyses revealed that osteomorphs are transcriptionally distinct from osteoclasts and macrophages and might be implicated in rare and common bone diseases in humans.
麦克唐纳及其同事报告了破骨细胞相关的动态机制，这些机制通过裂变导致成骨形态发生；成骨形态发生是具有运动能力和融合能力的细胞，能够形成破骨细胞，从而吸收骨。scRNA-seq 分析表明，成骨形态发生细胞在转录上与破骨细胞和巨噬细胞不同，可能与人类罕见和常见的骨骼疾病有关。
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