全基因组基因型-表型关联在微生物中的研究。

Genome-wide genotype-phenotype associations in microbes.

机构信息

MOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.

Division of Biology and Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA.

出版信息

J Biosci Bioeng. 2021 Jul;132(1):1-8. doi: 10.1016/j.jbiosc.2021.03.011. Epub 2021 Apr 21.

DOI:10.1016/j.jbiosc.2021.03.011

PMID:33895083

Abstract

The concept of a gene has been developed a lot since the Mendelian era owing to the rapid progress in molecular biology and informatics. To explore the nature of life, varieties of biological tools have been continuously established. Many achievements have been made to clarify the relationships between genotypes and phenotypes. However, it is still not completely clear that how traits of an organism are encoded by its genome. In this review, we will summarize and discuss representative works in systematical functional genomic studies in microbes. By analyzing their developmental progressions and limitations, we may have chances to design more powerful means to decipher the code of life.

摘要

自孟德尔时代以来，由于分子生物学和信息学的快速发展，基因的概念得到了很大的发展。为了探索生命的本质，各种生物工具不断被建立。许多成就已经取得，以阐明基因型和表型之间的关系。然而，仍然不完全清楚生物体的特征是如何由其基因组编码的。在这篇综述中，我们将总结和讨论微生物系统功能基因组研究的代表性工作。通过分析它们的发育进展和局限性，我们可能有机会设计更强大的手段来破解生命的密码。