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Clozapine prescribing and safety during COVID-19.氯氮平在2019冠状病毒病期间的处方开具与安全性
Asian J Psychiatr. 2021 Jun;60:102658. doi: 10.1016/j.ajp.2021.102658. Epub 2021 Apr 10.
2
A clinical conundrum: clozapine and COVID-19.一个临床难题：氯氮平与2019冠状病毒病
Australas Psychiatry. 2021 Oct;29(5):559-560. doi: 10.1177/1039856221992647. Epub 2021 Feb 24.
3
Clozapine toxicity and coronavirus disease 2019: A case report.氯氮平中毒与2019冠状病毒病：一例报告。
Schizophr Res. 2022 Feb;240:184-185. doi: 10.1016/j.schres.2022.01.008. Epub 2022 Jan 10.
4
Consensus statement on the use of clozapine during the COVID-19 pandemic.关于在2019冠状病毒病大流行期间使用氯氮平的共识声明。
J Psychiatry Neurosci. 2020 May 1;45(3):222-223. doi: 10.1503/jpn.200061.
5
COVID-19: Risks, Complications, and Monitoring in Patients on Clozapine.COVID-19：氯氮平治疗患者的风险、并发症和监测。
Pharmacopsychiatry. 2022 Jan;55(1):48-56. doi: 10.1055/a-1562-2521. Epub 2021 Sep 1.
6
[Clozapine prescription in the wake of the coronavirus (SARS CoV-2) outbreak: What measures? Why?].[新型冠状病毒（SARS-CoV-2）疫情期间的氯氮平处方：采取哪些措施？原因何在？]
Encephale. 2020 Jun;46(3S):S123-S124. doi: 10.1016/j.encep.2020.04.001. Epub 2020 Apr 3.
7
[Clozapine treatment and COVID-19: continue despite leukocytopenia and increase of clozapine serum levels].[氯氮平治疗与新冠肺炎：尽管出现白细胞减少和氯氮平血清水平升高仍继续治疗]
Tijdschr Psychiatr. 2021;63(6):406-411.
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Neutropenia in Patients With Clozapine-Treated Schizophrenia: An Effect of Clozapine or a Consequence of SARS-CoV-2 Infection? A Systematic Review.氯氮平治疗精神分裂症患者中性粒细胞减少症：是氯氮平的作用还是 SARS-CoV-2 感染的后果？系统评价。
Am J Ther. 2022;29(5):e544-e552. doi: 10.1097/MJT.0000000000001532. Epub 2022 Jun 24.
9
Clozapine Toxicity in the Setting of COVID-19.新型冠状病毒肺炎背景下的氯氮平毒性
Psychosomatics. 2020 Sep-Oct;61(5):577-578. doi: 10.1016/j.psym.2020.05.025. Epub 2020 May 30.
10
Clozapine Intoxication in COVID-19.新冠病毒感染中的氯氮平中毒
Am J Psychiatry. 2021 Feb 1;178(2):123-127. doi: 10.1176/appi.ajp.2020.20071039.

引用本文的文献

1
Impact of mRNA COVID-19 vaccination on hematological parameters in patients maintained on clozapine: A retrospective study from Qatar.新冠mRNA疫苗接种对服用氯氮平患者血液学参数的影响：来自卡塔尔的一项回顾性研究。
Explor Res Clin Soc Pharm. 2025 May 18;19:100614. doi: 10.1016/j.rcsop.2025.100614. eCollection 2025 Sep.
2
COVID-19 disease outcomes in patients receiving clozapine versus other antipsychotics: a national study in Qatar.接受氯氮平与其他抗精神病药物治疗的COVID-19患者的疾病转归：卡塔尔的一项全国性研究。
Front Psychiatry. 2025 May 8;16:1527378. doi: 10.3389/fpsyt.2025.1527378. eCollection 2025.
3
Clozapine and neutrophil response in patients of African descent: A six-month, multinational, prospective, open-label clinical trial.氯氮平和非洲裔患者的中性粒细胞反应：一项为期六个月、多国、前瞻性、开放性临床试验。
Schizophr Res. 2024 Jun;268:312-322. doi: 10.1016/j.schres.2023.08.002. Epub 2023 Aug 24.
4
Clinical impact of reducing the frequency of clozapine monitoring: controlled mirror-image cohort study.减少氯氮平监测频率的临床影响：对照镜像队列研究。
Br J Psychiatry. 2023 Aug;223(2):382-388. doi: 10.1192/bjp.2023.44.

本文引用的文献

1
Clozapine treatment and risk of COVID-19 infection: retrospective cohort study.氯氮平治疗与 COVID-19 感染风险：回顾性队列研究。
Br J Psychiatry. 2021 Jul;219(1):368-374. doi: 10.1192/bjp.2020.151.
2
Telephonic monitoring of patients on clozapine in the resource-poor setting during the COVID-19 pandemic.在新冠疫情期间资源匮乏地区对使用氯氮平的患者进行电话监测。
Schizophr Res. 2020 Aug;222:489-490. doi: 10.1016/j.schres.2020.05.062. Epub 2020 May 28.
3
COVID-19 Infection May Cause Clozapine Intoxication: Case Report and Discussion.新冠病毒感染可能导致氯氮平中毒：病例报告与讨论
Schizophr Bull. 2020 Jul 8;46(4):751. doi: 10.1093/schbul/sbaa070.
4
Clozapine is strongly associated with the risk of pneumonia and inflammation.氯氮平与肺炎和炎症风险密切相关。
Gen Psychiatr. 2020 Apr 16;33(2):e100183. doi: 10.1136/gpsych-2019-100183. eCollection 2020.
5
Clozapine treated patients and COVID-19: Ensuring continued care through collaboration.氯氮平治疗的患者与新型冠状病毒肺炎：通过合作确保持续护理。
Schizophr Res. 2020 Aug;222:507-508. doi: 10.1016/j.schres.2020.05.030. Epub 2020 May 14.
6
Consensus statement on the use of clozapine during the COVID-19 pandemic.关于在2019冠状病毒病大流行期间使用氯氮平的共识声明。
J Psychiatry Neurosci. 2020 May 1;45(3):222-223. doi: 10.1503/jpn.200061.
7
The prevalence of agranulocytosis and related death in clozapine-treated patients: a comprehensive meta-analysis of observational studies.氯氮平治疗患者中性粒细胞减少症及相关死亡的发生率：观察性研究的综合荟萃分析。
Psychol Med. 2020 Mar;50(4):583-594. doi: 10.1017/S0033291719000369. Epub 2019 Mar 12.
8
A qualitative exploration of clozapine prescribing and monitoring practices in the Arabian Gulf countries.阿拉伯海湾国家氯氮平处方和监测实践的定性探索。
Asian J Psychiatr. 2019 Jan;39:93-97. doi: 10.1016/j.ajp.2018.12.011. Epub 2018 Dec 21.
9
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.全球、区域和国家层面 195 个国家和地区 1990 年至 2017 年 354 种疾病和伤害导致的发病率、患病率和伤残损失寿命年：基于 2017 年全球疾病负担研究的系统分析。
Lancet. 2018 Nov 10;392(10159):1789-1858. doi: 10.1016/S0140-6736(18)32279-7. Epub 2018 Nov 8.

Clozapine prescribing and safety during COVID-19.

作者信息

Wadoo Ovais, Karim Mustafa Abdul, ElTorki Yassin, Riaz Sadaf, Latoo Javed, Alabdulla Majid

机构信息

Hamad Medical Corporation, Qatar.

Hamad Medical Corporation, Qatar; Weill Cornell Medicine-Qatar, Qatar.

出版信息

Asian J Psychiatr. 2021 Jun;60:102658. doi: 10.1016/j.ajp.2021.102658. Epub 2021 Apr 10.

DOI:10.1016/j.ajp.2021.102658
PMID:33895435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8035804/
Abstract
摘要