Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2.

作者信息

Huang Lihong, Yuen Terrence Tsz-Tai, Ye Zuodong, Liu Shuyan, Zhang Guoliang, Chu Hin, Yue Jianbo

机构信息

City University of Hong Kong Shenzhen Research Institute, Shenzhen, China.

Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.

出版信息

Signal Transduct Target Ther. 2021 Apr 24;6(1):168. doi: 10.1038/s41392-021-00584-6.

DOI:10.1038/s41392-021-00584-6

PMID:33895782

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8065329/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efba/8068721/ccc5cd10ade1/41392_2021_584_Fig1_HTML.jpg

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本文引用的文献

[1]

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses.

Nat Microbiol. 2020-2-24

[2]

Interfering with endolysosomal trafficking enhances release of bioactive exosomes.

Nanomedicine. 2019-5-30

[3]

The role of TRPMLs in endolysosomal trafficking and function.

Cell Calcium. 2015-7

[4]

Berbamine protects the heart from ischemia/reperfusion injury by maintaining cytosolic Ca(2+) homeostasis and preventing calpain activation.

Circ J. 2012-5-15

[5]

Viral calciomics: interplays between Ca2+ and virus.

Cell Calcium. 2009-7

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Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2.

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