Department of Emergency Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Emergency Department, The Second People's Hospital of Yunnan Province, 650021, Kunming, Yunnan, China.
Dokl Biochem Biophys. 2021 Mar;497(1):151-157. doi: 10.1134/S1607672921020022. Epub 2021 Apr 24.
Acute kidney injury (AKI), one of the frequently diagnosed and serious sepsis induced complication has high morbidity and mortality. The present study investigated the effect of cynaropicrin on AKI induced pathological damage in rat model in vivo. Treatment with cynaropicrin suppressed AKI induced urea nitrogen and creatinine in the rat serum in dose-dependent manner. Development of sepsis mediated renal injury in rats was also effectively prevented on treatment with cynaropicrin. Secretion of AKI-induced IL-1β and TNF-α in renal tissues was alleviated significantly in rats by cynaropicrin treatment. Additionally, in cynaropicrin-treated rats renal tissues AKI induced Bax expression was alleviated while as Bcl-2 was promoted compared to AKI rats. Cynaropicrin treatment improved the survival rate of the rats with AKI. Cynaropicrin inhibits renal tissue damage and increase survival rate in AKI rat model. The mechanism involves alleviation of inflammatory cytokine secretion and promotion of Bcl‑2 expression. Thus, cynaropicrin may be used as therapeutic agent for treatment of AKI.
急性肾损伤（AKI）是一种常见的诊断和严重的脓毒症诱发的并发症，具有高发病率和死亡率。本研究探讨了菊苣酸酯对脓毒症诱导的大鼠模型 AKI 病理损伤的影响。菊苣酸酯处理以剂量依赖性方式抑制 AKI 诱导的大鼠血清中尿素氮和肌酐。菊苣酸酯处理还能有效预防脓毒症介导的肾损伤的发展。菊苣酸酯处理显著减轻了 AKI 诱导的肾组织中白细胞介素-1β和肿瘤坏死因子-α的分泌。此外，与 AKI 大鼠相比，菊苣酸酯处理减轻了 AKI 大鼠肾组织中 AKI 诱导的 Bax 表达，同时促进了 Bcl-2 的表达。菊苣酸酯处理提高了 AKI 大鼠的存活率。菊苣酸酯抑制 AKI 大鼠模型的肾组织损伤并提高存活率。其机制涉及减轻炎症细胞因子的分泌和促进 Bcl-2 表达。因此，菊苣酸酯可作为治疗 AKI 的治疗剂。
