挪威老年重症监护患者的脆弱性与生存

Frailty and survival in elderly intensive care patients in Norway.

机构信息

Department of Anesthesiology and Intensive Care, Ålesund Hospital, Helse Møre and Romsdal Health Trust, Ålesund, Norway.

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.

出版信息

Acta Anaesthesiol Scand. 2021 Sep;65(8):1065-1072. doi: 10.1111/aas.13836. Epub 2021 May 7.

Abstract

BACKGROUND

Today, 10%-15% of Norwegian intensive care patients are ≥80 years. This proportion will increase significantly over the next 20 years, but it is unlikely that resources for intensive care increase correspondingly. Thus, it is important to establish which patients among elderly people will benefit from intensive care. The main objective of the study was to investigate the relationships between geriatric scoring tools and 30-day mortality.

METHODS

The study included 451 Norwegian patients ≥80 years who were included in two prospective European observation studies (VIP (very old intensive care patient)1 of VIP2). Both studies included clinical frailty scale (CFS) while VIP2 also obtained the geriatric scores, comorbidity and polypharmacy score (CPS), Short Form of Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), and Katz Activity of Daily Living score (Katz ADL).

RESULTS

Survival after 30 days was 59.9%. Risk factors for 30-day mortality were increasing Sequential Organ Failure Assessment (SOFA) score (odds ratio (OR) 1.30; confidence interval (CI) 95% 1.22-1.39) and (CFS) > 3 (CFS 4: OR 1.96 (CI 95% 1.01-3.81); CFS 5-9: OR 1.81 (CI) 95% 1.12-2.93)). Data from VIP2 showed that CFS was the only independent predictor of 30-day mortality when these scores were tested in multivariate analyses separately together with age, SOFA, and gender (OR 1.21 (95% CI 1.03-1.41)).

CONCLUSIONS

Elderly intensive care patients had a 30-day survival rate of 59.9%. Factors strongly associated with 30-day mortality were increasing SOFA score and increasing frailty (CFS). Other geriatric scores had no significant association with survival in multivariate analyses.

摘要

背景

如今,挪威重症监护病房的患者中有 10%-15%年龄在 80 岁以上。在未来 20 年内,这一比例将显著增加,但重症监护资源增加相应的可能性不大。因此,确定老年人中哪些患者将从重症监护中受益是很重要的。本研究的主要目的是研究老年评分工具与 30 天死亡率之间的关系。

方法

该研究纳入了 451 名年龄在 80 岁以上的挪威患者,他们参加了两项前瞻性欧洲观察研究(VIP(非常高龄重症监护患者)1 研究和 VIP2 研究)。这两项研究均包括临床虚弱量表(CFS),而 VIP2 还获得了老年评分、合并症和多药治疗评分(CPS)、简易认知衰退量表(IQCODE)和 Katz 日常生活活动评分(Katz ADL)。

结果

30 天后的生存率为 59.9%。30 天死亡率的危险因素包括序贯器官衰竭评估(SOFA)评分的增加(比值比(OR)1.30;95%置信区间(CI)1.22-1.39)和(CFS)>3(CFS 4:OR 1.96(CI 95% 1.01-3.81);CFS 5-9:OR 1.81(CI 95% 1.12-2.93))。来自 VIP2 的数据表明,当这些评分在多元分析中分别与年龄、SOFA 和性别一起测试时,CFS 是 30 天死亡率的唯一独立预测因素(OR 1.21(95% CI 1.03-1.41))。

结论

老年重症监护病房患者的 30 天生存率为 59.9%。与 30 天死亡率密切相关的因素是 SOFA 评分的增加和虚弱程度的增加(CFS)。其他老年评分在多元分析中与生存率无显著相关性。

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