Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Center Oulu, University Hospital of Oulu and University of Oulu, Oulu, Finland.
Department of Gastrointestinal Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Acta Obstet Gynecol Scand. 2021 Aug;100(8):1490-1496. doi: 10.1111/aogs.14165. Epub 2021 Jun 4.
A population-based register study utilizing three Finnish National Registers was carried out to determine whether uncomplicated appendicitis, complicated appendicitis and appendectomy without appendicitis are associated with a subsequent risk of requiring in vitro fertilization (IVF) treatment or a risk of ectopic pregnancy among reproductive-age women.
A total of 23 997 women who underwent appendectomy for uncomplicated or complicated appendicitis or for nonspecific abdominal pain or who had nonspecific abdominal pain without surgical procedures between 2000 and 2012 were included in the study. The later risks of IVF treatment requirement and ectopic pregnancy were assessed after uncomplicated appendicitis, complicated appendicitis and appendectomy without appendicitis. Women with nonspecific abdominal pain without surgical procedures served as the reference group.
The rates of later IVF treatment after uncomplicated appendicitis, complicated appendicitis and appendectomy without appendicitis were low (2.1%, 2.5% and 2.3%, respectively; p = 0.681). Neither appendicitis nor appendectomy was associated with the risk of requiring IVF treatment. The rate of ectopic pregnancy after uncomplicated and complicated appendicitis was very low (0.8%). Women with uncomplicated appendicitis had a significantly lower risk of ectopic pregnancy compared with patients with nonspecific abdominal pain.
Appendicitis, whether complicated or uncomplicated, and appendectomy without appendicitis does not increase the risk of requiring later IVF treatment or the risk of ectopic pregnancy.
本研究利用芬兰三个国家注册中心开展了一项基于人群的注册研究，旨在确定单纯性阑尾炎、复杂性阑尾炎和无阑尾炎的阑尾切除术是否与生殖期女性随后需要体外受精 (IVF) 治疗的风险或异位妊娠风险相关。
共纳入 23997 名在 2000 年至 2012 年间因单纯性或复杂性阑尾炎、非特异性腹痛或非特异性腹痛而接受阑尾切除术或无手术治疗的女性。评估了单纯性阑尾炎、复杂性阑尾炎和无阑尾炎阑尾切除术后发生 IVF 治疗需求和异位妊娠的风险。无手术治疗的非特异性腹痛女性作为参考组。
单纯性阑尾炎、复杂性阑尾炎和无阑尾炎阑尾切除术后发生 IVF 治疗的比例较低（分别为 2.1%、2.5%和 2.3%；p=0.681）。阑尾炎或阑尾切除术均与 IVF 治疗需求风险无关。单纯性和复杂性阑尾炎后异位妊娠的发生率非常低（0.8%）。与非特异性腹痛患者相比，单纯性阑尾炎患者异位妊娠的风险显著降低。
无论是否复杂，阑尾炎和无阑尾炎的阑尾切除术都不会增加随后需要 IVF 治疗的风险或异位妊娠的风险。
