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运动障碍急症。

Movement Disorder Emergencies.

机构信息

Division of Neurology, Lahey Hospital and Medical Center, Burlington, MA 01805, USA; Department of Neurology, Tufts University School of Medicine, Boston, MA 02111, USA.

Division of Neurology, Lahey Hospital and Medical Center, Burlington, MA 01805, USA.

出版信息

Neurol Clin. 2021 May;39(2):615-630. doi: 10.1016/j.ncl.2021.01.005. Epub 2021 Mar 31.

Abstract

Acute presentation of new movement disorders and acute decompensation of chronic movement disorders are uncommon but potentially life-threatening. Inadvertent or purposeful overdose of many psychiatric medications can result in acute life-threatening movement disorders including serotonin syndrome, neuroleptic malignant syndrome, and malignant catatonia. Early withdrawal of potentiating medications, treatment with benzodiazepines and other diagnosis-specific drugs, and providing appropriate supportive care including airway and breathing management, hemodynamic stabilization, fluid resuscitation, and renal support including possible hemodialysis are the mainstays of acute management. Many of these conditions require admission to the neurologic intensive care unit.

摘要

新出现的运动障碍和慢性运动障碍的急性恶化并不常见,但可能危及生命。许多精神科药物意外或故意过量服用可导致危及生命的急性运动障碍,包括血清素综合征、神经阻滞剂恶性综合征和恶性紧张症。急性治疗的主要方法包括:早期停用增效药物、使用苯二氮䓬类药物和其他特定于诊断的药物、提供适当的支持性护理,包括气道和呼吸管理、血流动力学稳定、液体复苏以及包括可能的血液透析在内的肾脏支持。许多这些情况需要入住神经重症监护病房。

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