天冬酰胺：细胞对线粒体功能障碍反应的关键代谢物。
Asparagine, a Key Metabolite in Cellular Response to Mitochondrial Dysfunction.
机构信息
Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
出版信息
Trends Cancer. 2021 Jun;7(6):479-481. doi: 10.1016/j.trecan.2021.04.001. Epub 2021 Apr 23.
The mitochondrial electron transport chain (ETC) has been an attractive target for cancer therapy due to its essentiality for tumor growth. Krall et al. found that under ETC dysfunction, a decrease in asparagine limits cancer cell proliferation and activates the integrated stress response, creating a therapeutically exploitable metabolic vulnerability.
线粒体电子传递链（ETC）因其对肿瘤生长的重要性而成为癌症治疗的一个有吸引力的靶点。Krall 等人发现，在 ETC 功能障碍下，天冬酰胺的减少会限制癌细胞的增殖并激活整体应激反应，从而产生一种可治疗的代谢脆弱性。
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