万古霉素粉末在全膝关节置换术中的疗效：一项单中心研究。
The efficacy of vancomycin powder in total knee arthroplasty: A single-center study.
机构信息
From the Department of Surgery (Aljuhani, Alhandi), Ministry of National Guard Health Affairs; from King Abdullah International Medical Research Center (Aljuhani, Alanazi, Alghafees); from the College of Medicine (Aljuhani, Alanazi, Alghafees), King Saud bin Abdulaziz University for Health Sciences and from the Department of Biostatistics (Sagor), Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
出版信息
Saudi Med J. 2021 May;42(5):550-554. doi: 10.15537/smj.2021.42.5.20210022.
OBJECTIVES
To assess the efficacy of vancomycin powder (VP) in total knee arthroplasty (TKA).
METHODS
The study design was retrospective cohort. All patients who underwent primary TKA for osteoarthritis between January 1, 2018, and March 1, 2020, in King Abdulaziz Medical City, Riyadh, Saudi Arabia were included (n=98). Of the total participants, 48 participants in the experimental group matched with 48 participants in the control group were included in the final study sample. Numerical variables are reported as means, standard deviations, and standard errors. The hypothesis was tested using the Chi-square test and independent t-test.
RESULTS
In comparison to the control group, intraoperative vancomycin powder (VP) did not decrease surgical site infection risk in the experimental group (=0.31).
CONCLUSION
We found no significant differences in the infection rates following primary TKA when using VP.
目的
评估万古霉素粉末（VP）在全膝关节置换术（TKA）中的疗效。
方法
研究设计为回顾性队列研究。纳入 2018 年 1 月 1 日至 2020 年 3 月 1 日在沙特阿拉伯利雅得阿卜杜勒阿齐兹国王医疗城接受原发性 TKA 治疗骨关节炎的所有患者（n=98）。在总参与者中，实验组有 48 名参与者与对照组的 48 名参与者匹配，纳入最终的研究样本。数值变量以平均值、标准差和标准误差表示。采用卡方检验和独立 t 检验检验假设。
结果
与对照组相比，实验组术中使用万古霉素粉末（VP）并未降低手术部位感染风险（=0.31）。
结论
我们发现使用 VP 后，初次 TKA 的感染率没有显著差异。
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