Lu Chun-Feng, Ma Jian-Hua, Su Jian-Bin, Wang Xue-Qin, Liu Wang-Shu, Ge Xiao-Qin
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, No. 32 Gong-qing-tuan Road, Nanjing 210012, China.
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People's Hospital of Nantong City, No. 6 North Hai-er-xiang Road, Nantong 226001, China.
Endocr J. 2021 Sep 28;68(9):1101-1107. doi: 10.1507/endocrj.EJ21-0039. Epub 2021 Apr 23.
The present study was designed to explore whether serum stromal cell-derived factor-1 (SDF-1) levels were associated with diabetic kidney disease (DKD). Serum SDF-1 levels were measured by sandwich ELISA. Patients with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m or a urinary albumin-to-creatinine ratio (UACR) ≥30 mg/g for 3 months were identified as having DKD. Among the recruited type 2 diabetic patients, 18.71% (n = 32) were found to have DKD, and the serum SDF-1 levels of these patients were higher than those of patients without DKD (p < 0.05). Serum SDF-1 levels were positively correlated with cystatin C levels, the UACR and DKD incidence (r = 0.330, 0.183 and 0.186, respectively, p < 0.05) and inversely related to eGFR (r = -0.368, p < 0.001). After adjusting for other clinical covariates by multivariate logistic regression analyses, serum SDF-1 levels were found to be an independent contributor to DKD, and the odds ratio (95% confidence interval) was 1.438 (1.041-1.986). Furthermore, receiver operating characteristic analysis revealed that the optimal SDF-1 cutoff value for indicating DKD was 5.609 ng/mL (its corresponding sensitivity was 82.00%, and specificity was 46.90%). Our results demonstrated that serum SDF-1 levels were closely associated with DKD and could be considered a potent indicator for DKD in patients with T2D.
本研究旨在探讨血清基质细胞衍生因子-1（SDF-1）水平是否与糖尿病肾病（DKD）相关。采用夹心酶联免疫吸附测定法（ELISA）检测血清SDF-1水平。估算肾小球滤过率（eGFR）<60 mL/min/1.73 m²或尿白蛋白与肌酐比值（UACR）≥30 mg/g持续3个月的患者被确定为患有DKD。在招募的2型糖尿病患者中，发现18.71%（n = 32）患有DKD，这些患者的血清SDF-1水平高于无DKD的患者（p < 0.05）。血清SDF-1水平与胱抑素C水平、UACR及DKD发病率呈正相关（r分别为0.330、0.183和0.186，p < 0.05），与eGFR呈负相关（r = -0.368，p < 0.001）。通过多因素逻辑回归分析校正其他临床协变量后，发现血清SDF-1水平是DKD的独立影响因素，比值比（95%置信区间）为1.438（1.041 - 1.986）。此外，受试者工作特征分析显示，指示DKD的最佳SDF-1临界值为5.609 ng/mL（其相应敏感性为82.00%，特异性为46.90%）。我们的结果表明，血清SDF-1水平与DKD密切相关，可被视为2型糖尿病患者DKD的有力指标。
