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根治性膀胱切除术后机器人辅助体内与体外新膀胱的功能结局:初步经验

Functional outcome of robotic-assisted intracorporeal versus extracorporeal neobladder following radical cystectomy: Initial experience.

作者信息

Khan Altaf, Vuppalapati Jeevan Kumar, Sarath Lavanya Raghu, Mujeeburahiman M, D'souza Nischith

机构信息

Department of Urology, Yenepoya Medical College, Mangaluru, India.

出版信息

Urol Ann. 2021 Jan-Mar;13(1):9-13. doi: 10.4103/UA.UA_132_19. Epub 2021 Jan 19.

Abstract

INTRODUCTION

Worldwide, the seventh most commonly diagnosed cancer in the male population is Bladder cancer (BC), while it drops to eleventh when both genders are considered. Radical cystectomy is the surgical treatment of choice for patients with all muscle-invasive and some nonmuscle invasive BCs. An orthotopic continent diversion (neobladder) is preferred whenever possible to achieve a better postoperative quality of life. We attempt to study the functional outcomes of intracorporeal neobladder (ICNB) versus extracorporeal neobladder (ECNB) (ICNB vs. ECNB).

MATERIALS AND METHODS

Forty patients who underwent robot-assisted radical cystectomy with neobladder in our institute during the period of March 2016-March 2018 were included in the study. An orthotopic neobladder (Studer method) was created in all our patients. Our main outcomes of interest were peak flow rates, residual urine, attainment of continence, and Pdet at qmax of the neobladder.

RESULTS

The mean age of patients in our study group was 54 ± 6 years. The mean body mass index was 23 ± 2 kg/m. The mean follow-up period was 24 ± 5 months. Twenty patients underwent ICNB and 20 patients underwent ECNB. The urodynamic assessment was done 1-year postprocedure. The same parameters applied to an intact bladder are used, and results analyzed by comparing it with other studies. Common in the initial postoperative period was incontinence which reduced substantially over time. After 1-year, 75% of patients did not require pads in the daytime, and a meager, <10% used more than one pad per day. There was no difference in outcome between both the groups, which was statistically significant.

CONCLUSION

Both ICNB and ECNB groups achieved urodynamically proven values of adequate bladder capacity and compliance. Daytime continence was excellent, and night time continence was good in both groups. Furthermore, there was no significant difference between both the groups as regards to urodynamic parameters. However, continence is attained little earlier in the ICNB group. There is no perceived superiority of ICNB over ECNB.

摘要

引言

在全球范围内,膀胱癌(BC)是男性人群中第七大最常被诊断出的癌症,若考虑男女两性,则降至第十一位。根治性膀胱切除术是所有肌层浸润性和部分非肌层浸润性膀胱癌患者的首选手术治疗方法。只要有可能,原位可控性尿流改道术(新膀胱)是首选,以实现更好的术后生活质量。我们试图研究体内新膀胱(ICNB)与体外新膀胱(ECNB)(ICNB对比ECNB)的功能结果。

材料与方法

本研究纳入了2016年3月至2018年3月期间在我院接受机器人辅助根治性膀胱切除术并构建新膀胱的40例患者。所有患者均采用原位新膀胱(Studer术式)。我们感兴趣的主要结果是新膀胱的最大尿流率、残余尿量、控尿能力以及最大尿流率时的膀胱充盈压。

结果

我们研究组患者的平均年龄为54±6岁。平均体重指数为23±2kg/m²。平均随访期为24±5个月。20例患者接受了ICNB,20例患者接受了ECNB。术后1年进行尿动力学评估。采用与完整膀胱相同的参数,并通过与其他研究进行比较来分析结果。术后初期常见尿失禁情况,但随着时间推移大幅减少。1年后,75%的患者白天无需使用尿垫,且仅有不到10%的患者每天使用超过一片尿垫。两组之间的结果无差异,具有统计学意义。

结论

ICNB组和ECNB组在尿动力学方面均证实具有足够的膀胱容量和顺应性。两组白天控尿情况良好,夜间控尿情况尚可。此外,两组在尿动力学参数方面无显著差异。然而,ICNB组控尿实现得稍早一些。未发现ICNB相对于ECNB有明显优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/8052906/cc2f46ef73d3/UA-13-9-g001.jpg

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