Islam Rafiad, Kaffman Arie
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.
Front Neurosci. 2021 Apr 9;15:657693. doi: 10.3389/fnins.2021.657693. eCollection 2021.
Early adversity () impairs myelin development in a manner that persists later in life across diverse mammalian species including humans, non-human primates, and rodents. These observations, coupled with the highly conserved nature of myelin development suggest that animal models can provide important insights into the molecular mechanisms by which EA impairs myelin development later in life and the impact of these changes on network connectivity, cognition, and behavior. However, this area of translational research has received relatively little attention and no comprehensive review is currently available to address these issues. This is particularly important given some recent mechanistic studies in rodents and the availability of new agents to increase myelination. The goals of this review are to highlight the need for additional pre-clinical work in this area and to provide specific examples that demonstrate the potential of this work to generate novel therapeutic interventions that are highly needed.
早期逆境会损害髓鞘发育，这种损害在包括人类、非人灵长类动物和啮齿动物在内的多种哺乳动物的生命后期持续存在。这些观察结果，再加上髓鞘发育的高度保守性，表明动物模型可以为早期逆境在生命后期损害髓鞘发育的分子机制以及这些变化对网络连通性、认知和行为的影响提供重要见解。然而，这一转化研究领域受到的关注相对较少，目前尚无全面的综述来解决这些问题。鉴于最近在啮齿动物身上进行的一些机制研究以及新型髓鞘形成促进剂的出现，这一点尤为重要。本综述的目的是强调该领域额外的临床前研究工作的必要性，并提供具体实例，以证明这项工作在产生急需的新型治疗干预措施方面的潜力。
