Nardelli E, Steck A J, Barkas T, Schluep M, Jerusalem F
Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Ann Neurol. 1988 May;23(5):524-8. doi: 10.1002/ana.410230517.
We demonstrated that an IgM M-protein from a patient with motor neuron syndrome had antibody activity against gangliosides GM1, GD1b, and asialo GM1. Studies with a sugar-binding lectin suggested that the epitope in the patient's M-IgM involved the Gal(beta 1-3) GalNAc moiety. Immunohistological techniques demonstrated staining of axons in the lumbar roots, granular cells, and white matter in the cerebellum by the patient's M-IgM. We propose that, in this case, an autoimmune mechanism of motor neuron syndrome associated with a monoclonal protein is most likely.
