Cha Myeounghoon, Kwon Minjee, Park Misun, Oh Jin-Hwan, Sung Kang-Keyng, Lee Bae Hwan
Department of Physiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Nursing, Kyungil University, Gyeongsan, Republic of Korea.
Integr Med Res. 2021 Sep;10(3):100720. doi: 10.1016/j.imr.2021.100720. Epub 2021 Feb 17.
Behçet's disease (BD) is a chronic inflammatory systemic disease that affects multiple organs. The causes of BD are still unknown, but it is primarily characterized by autoimmune reaction in the blood vessels. Current research focuses on treatments that can reduce the non-typical inflammatory responses of BD. Nevertheless, studies on improving the inflammatory effect of BD using inflammation mechanisms are still insufficient. Therefore, we conducted the integrated treatments related to inflammation modulation and achieved alleviation of symptoms in BD mice.
To understand the complex etiology of BD and compare its management, the herpes simplex virus (HSV)-induced BD mouse model was used. In order to alleviate the inflammatory response in BD mice, Taraxaci Herba (TH, herbal medicine), R7050-a TNFα inhibitor, and a mixture of TH and R7050 were injected for 2 weeks repetitively. The SCORAD index was examined to evaluate the cutaneous inflammations. In addition, histological changes and inflammatory factors were analyzed.
Repetitive injection of TH and/or R7050 reduced the symptoms of BD and significantly decreased IL-6, IL-1β, and TNFα in blood sera. Moreover, this treatment reduced the ulcers and the deterioration of skin.
The results of our study showed that the down-regulation of inflammatory factors is related to the control of immune responses in BD models, suggesting that a mixed drug treatment may be more effective in improving the condition of BD.
白塞病（BD）是一种影响多个器官的慢性炎症性全身性疾病。BD的病因尚不清楚，但其主要特征是血管中的自身免疫反应。目前的研究集中在能够减少BD非典型炎症反应的治疗方法上。然而，利用炎症机制改善BD炎症效应的研究仍然不足。因此，我们进行了与炎症调节相关的综合治疗，并在BD小鼠中实现了症状缓解。
为了了解BD的复杂病因并比较其治疗方法，使用了单纯疱疹病毒（HSV）诱导的BD小鼠模型。为了减轻BD小鼠的炎症反应，反复注射蒲公英（TH，草药）、R7050（一种TNFα抑制剂）以及TH和R7050的混合物，持续2周。检查SCORAD指数以评估皮肤炎症。此外，分析了组织学变化和炎症因子。
反复注射TH和/或R7050减轻了BD的症状，并显著降低了血清中的IL-6、IL-1β和TNFα。此外，这种治疗减少了溃疡和皮肤恶化。
我们的研究结果表明，炎症因子的下调与BD模型中免疫反应的控制有关，这表明混合药物治疗可能在改善BD病情方面更有效。
