Kawarada Y, Ogura Y, Mizumoto R
1st Dept. of Surgery, Mie University School of Medicine.
Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-1):763-9.
The incidence of cancer of the biliary tract has been recently increasing, but the results of treatment have been unsatisfactory. During the last 10 years and 10 months, 128 cases of carcinoma of the biliary tract, including 64 cases of the gallbladder and the bile duct, respectively, were admitted. Some 98 (86%) out of the 113 cases were resected, with a low curative surgery rate of 32.7%. The curative surgery even resulted in recurrence with a few long-term survivors, so multimodal treatment should be considered for all cases. In non-curative resection, the 2-year cumulative survival rate of gallbladder carcinoma was 25% with radiation and chemotherapy, compared to the group without such treatment, all of whom died within 2 years after surgery. In cancer of the bile duct, similar results were obtained, so multimodal treatment should be administered especially in non-curative resection cases. In 1985 Mizumoto's group reviewed 1614 cases of gallbladder carcinoma and bile duct carcinoma collected from 22 institutions in Japan. The resectability and curative rate have been increasing, and the survival rates of both groups have slightly increased. Multimodal treatment has involved radiation therapy in 13.6% and chemotherapy in 44.1% of the cases. A two-year cumulative survival rate increased in non-curative resection patients treated with multimodal treatment.
近年来，胆道癌的发病率一直在上升，但治疗效果却不尽人意。在过去的10年零10个月里，共收治了128例胆道癌患者，其中胆囊癌和胆管癌分别为64例。在113例患者中，约98例（86%）接受了手术切除，根治性手术率较低，为32.7%。根治性手术甚至会导致复发，长期存活者寥寥无几，因此所有病例都应考虑采用多模式治疗。在非根治性切除术中，胆囊癌患者接受放疗和化疗后的2年累积生存率为25%，而未接受此类治疗的患者在术后2年内全部死亡。胆管癌也得到了类似的结果，因此尤其在非根治性切除病例中应采用多模式治疗。1985年，水本小组回顾了从日本22家机构收集的1614例胆囊癌和胆管癌病例。可切除性和治愈率一直在提高，两组的生存率也略有上升。多模式治疗包括13.6%的病例接受放射治疗和44.1%的病例接受化疗。接受多模式治疗的非根治性切除患者的2年累积生存率有所提高。
