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用于肺癌放射治疗计划的四维磁共振成像的实验评估

Experimental evaluation of four-dimensional Magnetic Resonance Imaging for radiotherapy planning of lung cancer.

作者信息

Perkins Terry, Lee Danny, Simpson John, Greer Peter, Goodwin Jonathan

机构信息

Blacktown Cancer & Haematology Centre, Blacktown Hospital, NSW, Australia.

School of Physics, University of Sydney, Australia.

出版信息

Phys Imaging Radiat Oncol. 2021 Jan 7;17:32-35. doi: 10.1016/j.phro.2020.12.006. eCollection 2021 Jan.

DOI:10.1016/j.phro.2020.12.006
PMID:33898775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8058028/
Abstract

Radiotherapy planning for lung cancer typically requires both 3D and 4D Computed Tomography (CT) to account for respiratory related movement. 4D Magnetic Resonance Imaging (MRI) with self-navigation offers a potential alternative with greater reliability in patients with irregular breathing patterns and improved soft tissue contrast. In this study 4D-CT and a 4D-MRI Radial Volumetric Interpolated Breath-hold Examination (VIBE) sequence was evaluated with a 4D phantom and 13 patient respiratory patterns, simulating tumour motion. Quantification of motion related tumour displacement in 4D-MRI and 4D-CT found no statistically significant difference in mean motion range. The results demonstrated the potential viability of 4D-MRI for lung cancer treatment planning.

摘要

肺癌的放射治疗计划通常需要三维和四维计算机断层扫描（CT）来考虑与呼吸相关的运动。具有自导航功能的四维磁共振成像（MRI）为呼吸模式不规则的患者提供了一种更可靠的潜在替代方案，并且改善了软组织对比度。在本研究中，使用四维体模和13种患者呼吸模式对四维CT和四维MRI径向容积插值屏气检查（VIBE）序列进行了评估，模拟肿瘤运动。对四维MRI和四维CT中与运动相关的肿瘤位移进行量化，发现平均运动范围在统计学上没有显著差异。结果证明了四维MRI在肺癌治疗计划中的潜在可行性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9606/8058028/5eb870e55127/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9606/8058028/ee787d04654f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9606/8058028/5eb870e55127/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9606/8058028/ee787d04654f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9606/8058028/5eb870e55127/gr2.jpg

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