长链非编码RNA的核功能成为研究焦点。

Song Zhenxing, Lin Jiamei, Li Zhengguo, Huang Chuan

School of Life Sciences, Chongqing University, Chongqing, 401331, China.

Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, Chongqing, 401331, China.

Noncoding RNA Res. 2021 Mar 27;6(2):70-79. doi: 10.1016/j.ncrna.2021.03.002. eCollection 2021 Jun.

Long noncoding RNAs (lncRNAs), defined as untranslated and tightly-regulated transcripts with a length exceeding 200 nt, are common outputs of the eukaryotic genome. It is becoming increasingly apparent that many lncRNAs likely serve as important regulators in a variety of biological processes. In particular, some of them accumulate in the nucleus and function in diverse nuclear events, including chromatin remodeling, transcriptional regulation, RNA processing, DNA damage repair, etc. Here, we unite recent progresses on the functions of nuclear lncRNAs and provide insights into the future research directions of this field.

长链非编码RNA（lncRNAs）被定义为长度超过200个核苷酸的未翻译且受到严格调控的转录本，是真核基因组的常见产物。越来越明显的是，许多lncRNAs可能在多种生物学过程中作为重要的调节因子发挥作用。特别是，其中一些在细胞核中积累，并在各种核事件中发挥作用，包括染色质重塑、转录调控、RNA加工、DNA损伤修复等。在这里，我们总结了关于核lncRNAs功能的最新进展，并对该领域未来的研究方向提供了见解。