先天性肾上腺皮质增生症患者唾液中雄烯二酮的节律变化
Androstenedione rhythms in saliva in congenital adrenal hyperplasia.
作者信息
Young M C, Walker R F, Riad-Fahmy D, Hughes I A
机构信息
Department of Child Health, University of Wales College of Medicine, Cardiff.
出版信息
Arch Dis Child. 1988 Jun;63(6):624-8. doi: 10.1136/adc.63.6.624.
Serial samples of saliva were collected at home by 17 patients being treated for congenital adrenal hyperplasia to determine the circadian rhythm of androstenedione as an index of therapeutic control. Single samples of blood for measurement of plasma testosterone, 170H-progesterone, and androstenedione concentrations were collected from these and a further seven patients for comparison. Plasma androstenedione concentrations showed a close correlation with plasma concentrations of 170H-progesterone and testosterone. There was a strong correlation between the salivary androstenedione profiles and plasma testosterone concentrations in pubertal girls. Concentrations of androstenedione in saliva decreased during the day but remained raised at each sampling time in relation to plasma testosterone concentrations. Salivary androstenedione profiles are shown as nomograms to distinguish the degree of therapeutic control. The concentration of androstenedione, measured in plasma or saliva, is an alternative marker to monitor control of treatment in congenital adrenal hyperplasia. The measurement in saliva is a useful index of androgen production when blood sampling is difficult.
17名接受先天性肾上腺皮质增生症治疗的患者在家中采集了系列唾液样本，以确定雄烯二酮的昼夜节律，作为治疗控制的指标。从这些患者以及另外7名患者中采集了单份血液样本，用于测量血浆睾酮、17α-羟孕酮和雄烯二酮浓度，以便进行比较。血浆雄烯二酮浓度与血浆17α-羟孕酮和睾酮浓度密切相关。青春期女孩唾液中雄烯二酮水平与血浆睾酮浓度之间存在强相关性。唾液中雄烯二酮浓度在白天降低，但在每个采样时间相对于血浆睾酮浓度仍保持升高。唾液雄烯二酮水平以列线图显示，以区分治疗控制程度。血浆或唾液中测得的雄烯二酮浓度是监测先天性肾上腺皮质增生症治疗控制情况的另一种标志物。当难以采集血样时，唾液测量是雄激素产生的有用指标。
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