Sizonenko P C, Paunier L
J Clin Endocrinol Metab. 1975 Nov;41(5):894-904. doi: 10.1210/jcem-41-5-894.
In 104 normal boys, aged 7 to 14 years (bone ages 5 to 15 years), plasma dehydroepiandrosterone (DHEA) rose from 52.7 at 7 years, to 112.0 ng/100 ml at 10 years. A further rise occurred at 12 years (188 ng/100 ml). In relation to the bone age, DHEA increased from a mean plasma level of 31.1 at a bone age of 5 years to 77.1 ng/100 ml at one of 7 years. Further increases were observed with mean values of 163.2 at a bone age of 11 years, and of 221.2 at a bone age of 12 years, with a maximum of 333.4 ng/100 ml at bone ages of 14-15 years. The first significant increase of plasma testosterone (T) was noted at a bone age of 12 years (54.8 ng/100 ml). The major rise of T was preceded by the rise of plasma LH and was accompanied by the rise of plasma FSH. Plasma DHEA and T were also measured in 123 normal girls, ages 6 to 13 years (bone ages 5 to 15 years). DHEA rose significantly from a mean level of 44.7 at 6 years, to 80.9 ng/100 ml at 8 years, with further increases between 9 and 10 years and between 10 and 11 years. In relation to bone age, DHEA increased significantly from a mean plasma concentration of 30.9 at a bone age of 5 years, to that of 58.6 ng/100 ml at 7 years. Further increases were observed with values of 191.1 at a bone age of 10 years and 485.6 ng/100 ml at a bone age of 13 years. The first significant rise of testosterone (T) occurred at 10 years of both chronological and bone age. DHEA rose before the increase of gonadotropins. The major rise of T at a bone age of 10 years occurred concurrently with increases in plasma FSH and LH. Low levels of DHEA were observed in Addison's disease. In hypogonadotropin hypogonadism and in anorchia, DHEA levels were normal, suggesting that DHEA is produced primarily in the adrenal gland. In seven girls with early adrenarche, plasma concentrations of DHEA were in the upper range of normal values, whereas T levels were within the normal range. Conversely in girls with late adrenarche, plasms DHEA was lower than normal but T was within the normal limits. The elevation of DHEA prior to the first signs of puberty suggests that DHEA may play a role in the maturation of the hypothalamic-hypophysealgonadal axis. However, the mechanism that triggers the secretion of DHEA is not known.
在104名7至14岁（骨龄5至15岁）的正常男孩中，血浆脱氢表雄酮（DHEA）从7岁时的52.7，升至10岁时的112.0 ng/100 ml。12岁时进一步升高（188 ng/100 ml）。相对于骨龄，DHEA从骨龄5岁时的平均血浆水平31.1，增加到7岁时的77.1 ng/100 ml。随着骨龄增加，11岁时平均值为163.2，12岁时为221.2，在骨龄14 - 15岁时最高达到333.4 ng/100 ml。血浆睾酮（T）首次显著升高出现在骨龄12岁时（54.8 ng/100 ml）。T的主要升高之前是血浆促黄体生成素（LH）的升高，并伴有血浆促卵泡生成素（FSH）的升高。还对123名6至13岁（骨龄5至15岁）的正常女孩进行了血浆DHEA和T的测量。DHEA从6岁时的平均水平44.7显著升至8岁时的80.9 ng/100 ml，在9至10岁以及10至11岁之间进一步升高。相对于骨龄，DHEA从骨龄5岁时的平均血浆浓度30.9，显著增加到7岁时的58.6 ng/100 ml。随着骨龄增加，10岁时为191.1，13岁时为485.6 ng/100 ml。睾酮（T）的首次显著升高出现在实际年龄和骨龄均为10岁时。DHEA在促性腺激素升高之前升高。骨龄10岁时T的主要升高与血浆FSH和LH的增加同时发生。艾迪生病患者中观察到DHEA水平较低。在低促性腺激素性性腺功能减退和无睾症患者中，DHEA水平正常，表明DHEA主要在肾上腺产生。在7名性早熟女孩中，血浆DHEA浓度处于正常范围的上限，而T水平在正常范围内。相反，在性发育延迟的女孩中，血浆DHEA低于正常，但T在正常范围内。青春期最初迹象出现之前DHEA的升高表明，DHEA可能在下丘脑 - 垂体 - 性腺轴的成熟中起作用。然而，触发DHEA分泌的机制尚不清楚。
