Mengesha Bethlehem, Levi Daniela, Kroonenberg Moran, Koren Ronit, Golik Ahuva, Koren Shlomit
Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Isr Med Assoc J. 2021 Apr;23(4):245-250.
Hypomagnesemia (serum magnesium level < 1.7 mg/dl) occurs more frequently in patients with type 2 diabetes mellitus (T2DM).Serum magnesium levels are not routinely tested in hospitalized patients, including in hospitalized patients with T2DM.
To evaluate the prevalence of hypomagnesemia among hospitalized T2DM patients treated with proton pump inhibitors (PPIs) and/or diuretics.
A total of 263 T2DM patients hospitalized in general departments were included in the study and were further divided into four groups: group 1 (patients not treated with PPIs or diuretics), group 2 (patients treated with PPIs), group 3 (patients treated with diuretics), and group 4 (patients treated with both PPIs and diuretics). Blood and urine samples were taken during the first 24 hours of admission. Electrocardiogram was performed on admission.
Of the 263 T2DM patients, 58 (22.1%) had hypomagnesemia (serum magnesium level < 1.7 mg/dl). Patients in group 2 had the lowest mean serum magnesium level (1.79 mg/dl ± 0.27). Relatively more patients with hypomagnesemia were found in group 2 compared to the other groups, although a statistically significant difference was not observed. Significantly more patients in group 3 and 4 had chronic renal failure. Patients with hypomagnesemia had significantly lower serum calcium levels.
Hospitalized T2DM patients under PPI therapy are at risk for hypomagnesemia and hypocalcemia.
低镁血症（血清镁水平<1.7mg/dl）在2型糖尿病（T2DM）患者中更为常见。住院患者，包括住院的T2DM患者，血清镁水平通常不进行常规检测。
评估接受质子泵抑制剂（PPI）和/或利尿剂治疗的住院T2DM患者中低镁血症的患病率。
本研究纳入了263例普通科室住院的T2DM患者，并进一步分为四组：第1组（未接受PPI或利尿剂治疗的患者）、第2组（接受PPI治疗的患者）、第3组（接受利尿剂治疗的患者）和第4组（接受PPI和利尿剂治疗的患者）。入院后24小时内采集血样和尿样。入院时进行心电图检查。
263例T2DM患者中，58例（22.1%）有低镁血症（血清镁水平<1.7mg/dl）。第2组患者的平均血清镁水平最低（1.79mg/dl±0.27）。与其他组相比，第2组中低镁血症患者相对较多，尽管未观察到统计学上的显著差异。第3组和第4组中慢性肾衰竭患者明显更多。低镁血症患者的血清钙水平明显较低。
接受PPI治疗的住院T2DM患者有发生低镁血症和低钙血症的风险。
