Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, China.
Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):6442-6448. doi: 10.1080/14767058.2021.1914581. Epub 2021 Apr 25.
Little is known about the association between maternal history of dysmenorrhea and perinatal outcomes. The aim of this study was to investigate the association between maternal history of dysmenorrhea and low birth weight (LBW).
A total of 6754 pregnant women were recruited from the ongoing prospective cohort study in Guangxi, China, in 2015-2018. Information on the maternal history of dysmenorrhea was obtained by questionnaires including visual analog scale (VAS) questions during the first antenatal care visit. The association of maternal history of dysmenorrhea and LBW was evaluated using logistic regression analyses adjusted for confounding factors (infant sex, maternal age, parity, pre-pregnancy body mass index (BMI) (kg/m), gestational age, alcohol use during pregnancy, passive smoking, and occupational status).
Mothers with a history of dysmenorrhea were more likely to give birth to LBW infants (adjusted odds ratio (OR)=1.44; 95% confidence interval (CI): 1.12, 1.83). Among women with a history of dysmenorrhea, women ≥29 years old (adjusted OR 1.46; 95% CI 1.02, 2.10), multiparous (adjusted OR 1.59, 95% CI 1.12, 2.25), and women gave birth to female infant (adjusted OR = 1.53, 95% CI = 1.11, 2.11) had a higher risk of LBW.
As the first cohort study to investigate the association between maternal history of dysmenorrhea and LBW, our study shows that dysmenorrhea may increase the risk of LBW.
关于痛经史与围产结局的关系知之甚少。本研究旨在探讨痛经史与低出生体重（LBW）的关系。
2015 年至 2018 年，在中国广西进行的一项正在进行的前瞻性队列研究中，共招募了 6754 名孕妇。通过问卷调查获得了母亲痛经史的信息，其中包括第一次产前检查时的视觉模拟量表（VAS）问题。使用逻辑回归分析调整了混杂因素（婴儿性别、母亲年龄、产次、孕前体重指数（BMI）（kg/m）、胎龄、孕期饮酒、被动吸烟和职业状况），评估了母亲痛经史与 LBW 的关系。
有痛经史的母亲更有可能生出 LBW 婴儿（调整后的优势比（OR）=1.44；95%置信区间（CI）：1.12，1.83）。在有痛经史的女性中，年龄≥29 岁的女性（调整后的 OR 1.46；95%CI 1.02，2.10）、多产妇（调整后的 OR 1.59；95%CI 1.12，2.25）和分娩女婴的女性（调整后的 OR = 1.53；95%CI = 1.11，2.11）LBW 的风险更高。
作为第一项研究痛经史与 LBW 关系的队列研究，本研究表明痛经可能增加 LBW 的风险。
